Effects of rTMS on Brain Plasticity and Motor Learning in Healthy People.
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Healthy
- Sponsor
- University of Geneva, Switzerland
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Motor performance in consolidation test
- Last Updated
- 6 years ago
Overview
Brief Summary
Recent studies have identified new neurobiological biomarker (i.e. functional connectivity of the parietal cortex) of motor learning among healthy people. This enables to refine our current model of motor learning wherein specific cortical processes are key factors for motor acquisition. Furthermore, recent evidence suggests that new technical approaches such as repetitive magnetic stimulation (rTMS) can efficiently influence this key factor. However, up to now, no rTMS studies have target this new biomarker. Therefore, the effect of rTMS are unknown. Hence, the investigators want to develop a new rTMS setup able to induce specific brain processes in healthy individuals that are likely to benefit. This has the potential to obtain critical information in order to improve treatment of motor re-learning in patients with neurological diseases.
Detailed Description
Participants will participate in 1 session of neuronavigated (TMS Navigator, Localite, Schloss Birlinghoven, D-53757, Sankt Augustin, Germany ) iTBS (patterned form of rTMS) coupled with motor learning. Participants will be randomly assigned to one of 2 groups: real iTBS over parietal cortex and sham iTBS over the parietal cortex. One day before (Day1) and after the motor learning (Day 2), participants will undergo high-density 128-channel resting state electroencephalography (EEG) and motor evoked potential (MEP) in order to characterize the effects of rTMS on our markers of plasticity. Performance on the task will be measure immediately after learning (Day 2) and again 24h later (Day 3) in order to test for retention and offline consolidation (time and errors). The task will consist in realizing a computerized mirror-drawing task, in which right-left movements of the mouse were reversed on the screen.
Investigators
Pierre Nicolo
Principal Investigator
University of Geneva, Switzerland
Eligibility Criteria
Inclusion Criteria
- •man or woman aged between 18-40 years,
- •ability to give informed consent,
- •ability to follow protocol instructions,
- •normal or corrected-to-normal vision,
Exclusion Criteria
- •history of epileptic seizure (ci. TMS),
- •skull breach (ci. TMS),
- •metallic object in the brain (ci. TMS),
- •pacemaker (ci. TMS),
- •severe co-morbidity (ex, traumatic, rheumatologic, neurodegenerative diseases),
- •pregnancy.
Outcomes
Primary Outcomes
Motor performance in consolidation test
Time Frame: after training (Day 3)
Difference in error rate and speed improvement in active and sham groups (learned task)
Secondary Outcomes
- Resting state EEG connectivity in active and sham groups(Before (Day 1) and after training (Day 2))
- Motor Evoked Potential (MEPs) Amplitudes (peak to peak)(Before (Day 1) and after training (Day 2))