Urinary NGAL Acute Kidney Injury After Stored Red Blood Cells Transfusion in Critically Ill Patients.

Completed

• Conditions: Anemia; Acute Kidney Injury
• Interventions: Diagnostic Test: urinary NGAL

• Registration Number: NCT03560921
• Lead Sponsor: Kasr El Aini Hospital

Brief Summary

The study aims to explore the association of the novel urinary bio marker NGAL with the age of PRBCs(packed red blood cells) transfusion in critically ill patients.

Detailed Description

The investigators will measure the urinary NGAL in all patients who received blood transfusion in the intensive care unit during the study period. The age of PRBCs transfusion will be correlated with the incidence of AKI. The rise of NGAL and serum creatinine will be used to diagnose AKI (Acute Kidney Injury).

Study Timeline

• Study Start: 2017-06-02
• Primary Completion: 2017-12-05
• Study Completion: 2017-12-05
• Status Verified: 2018-06
• Study First Submitted: 2018-06-05
• Study First Submitted QC: 2018-06-15
• Last Update Submitted: 2018-06-15
• Study First Posted: 2018-06-18
• Last Update Posted: 2018-06-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 147

Inclusion Criteria

• Any patients admitted to the intensive care unit.

Exclusion Criteria

• patients who have established AKI at the time of recruitment

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Fresh blood transfusion	urinary NGAL	measurement of urinary NGAL
Stored blood transfusion	urinary NGAL	measurement of urinary NGAL

Primary Outcome Measures

Name	Time	Method
Incidence of AKI	within 30 days	Diagnosis of AKI by rise of serum creatinine

Trial Locations

Locations (1)

Cairo university hospitals; 🇪🇬 Cairo, Egypt