A feasibility trial of cord blood cell transplantation for adult T cell leukemia/lymphoma following reduced intensity conditioning regimen - A feasibility trial of cord blood cell transplantation for adult T cell leukemia/lymphoma following reduced intensity conditioning regimen (ATL-NST-5)

Grant for anticancer project from Ministry of Health, Welfare, and Labor of Japan0 sites15 target enrollmentMay 14, 2012

Overview

Phase: 未知
Intervention: Not specified
Conditions: Not specified
Sponsor: Grant for anticancer project from Ministry of Health, Welfare, and Labor of Japan
Enrollment: 15
Status: Completed
Last Updated: 2 years ago

No summary available.

Registry

who.int

Start Date

May 14, 2012

End Date

April 1, 2014

Last Updated

2 years ago

Study Type

Interventional

Sex

All

Sponsor

Grant for anticancer project from Ministry of Health, Welfare, and Labor of Japan

•(1\) A patient is uneligible if he (she) has (a) to (d). (a) Resting ejection fraction bellow 50% by UCG. (b) SaO2 bellow 90% in room air. (c) Serum Cr level above 2\.0 mg/dL. (d) CCr bellow 20 mL/min/m2\. (e) T.Bil level above 2\.0 mg/dL or GPT over 4 times of upper limit. (2\) Uncontrollable active infection. (3\) Active CNS lesion at registration. (4\) Woman who is pregnant, possibly pregnant or breast feeding (5\) On or taking major tranquilizer, antidepressant, antimanic. (6\) History of adverse reaction for the agents included in the protocol in conditioning (fludarabine, melphalan), in GVHD prophylaxis (tacrorimus, MMF, steroids) and G\-CSF. (7\) Recipient of previous allogeneic hematopoietic stem cell transplantation. (8\) Positive for HIV antibody. (9\) Positive for HBs antigen. (10\) Have an active cancer.