Study of the Effects of High Dose Aflibercept Injected Into the Eye of Patients With an Age-related Disorder That Causes Loss of Vision Due to Growth of Abnormal Blood Vessels at the Back of the Eye
- Conditions
- Neovascular Age-Related Macular Degeneration
- Interventions
- Registration Number
- NCT04423718
- Lead Sponsor
- Bayer
- Brief Summary
In this study researchers want to learn more about changes in visual acuity (clarity of vision) with a high dose treatment with Aflibercept (Eylea) in patients suffering from neovascular age-related macular degeneration (nAMD). Neovascular AMD is an eye disease that causes blurred vision or a blind spot due to abnormal blood vessels that leak fluid or blood into the light sensitive lining inside the eye (retina). The fluid buildup causes the central part of the retina (macula) responsible for sharp, straight-ahead vision to swell and thicken (edema), which distorts vision.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 1011
- Active subfoveal CNV secondary to nAMD, including juxtafoveal lesions that affect the fovea as assessed in the study eye.
- Total area of CNV (including both classic and occult components) must comprise greater than 50% of the total lesion area in the study eye.
- BCVA ETDRS letter score of 78 to 24 (corresponding to a Snellen equivalent of approximately 20/32 to 20/320) in the study eye.
- Decrease in BCVA determined to be primarily the result of nAMD in the study eye.
- Presence of IRF and/or SRF affecting the central subfield of the study eye on OCT.
- Contraceptive use by men or women should be consistent with local regulations regarding the methods of highly effective contraception for those participating in clinical studies.
- Other protocol-specified inclusion criteria.
Additional inclusion criteria for Year 3:
- At least one BCVA value and one central subfield retinal thickness (CST) value from measurements at one of the following visits: Visit 24 (Week 84), Visit 25 (Week 88) or Visit 26 (Week 92).
- Participant is enrolled at a site that participates in the extension period.
- Causes of CNV other than nAMD in the study eye.
- Scar, fibrosis, or atrophy involving the central subfield in the study eye.
- Presence of retinal pigment epithelial tears or rips involving the central subfield in the study eye.
- Uncontrolled glaucoma (defined as IOP >25 mmHg despite treatment with anti-glaucoma medication) in the study eye.
- History of idiopathic or autoimmune uveitis in the study eye.
- Myopia of a spherical equivalent of at least 8 diopters in the study eye prior to any refractive or cataract surgery.
- History or clinical evidence of diabetic retinopathy, diabetic macular edema, or any retinal vascular disease other than nAMD in either eye.
- Evidence of extraocular or periocular infection or inflammation (including infectious blepharitis, keratitis, scleritis, or conjunctivitis) in either eye at the time of screening/randomization.
- Uncontrolled blood pressure (defined as systolic >160 mmHg or diastolic >95 mmHg).
- Any prior or concomitant ocular (in the study eye) or systemic treatment (with an investigational or approved, anti-VEGF or other agent) or surgery for nAMD, except dietary supplements or vitamins.
- Other protocol-specified exclusion criteria
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Aflibercept 2q8 Aflibercept High Dose VEGF Trap-Eye (BAY86-5321) In the double-masked study part (Years 1 and 2), Aflibercept 2 mg administered every 8 weeks after a loading phase. (Active Comparator) In Year 3, high dose aflibercept administered according to individual patient response. (Experimental) Aflibercept 2q8 Aflibercept VEGF Trap-Eye (Eylea, BAY86-5321) In the double-masked study part (Years 1 and 2), Aflibercept 2 mg administered every 8 weeks after a loading phase. (Active Comparator) In Year 3, high dose aflibercept administered according to individual patient response. (Experimental) Aflibercept HDq12 Aflibercept High Dose VEGF Trap-Eye (BAY86-5321) Aflibercept high dose (HD) administered every 12 weeks after an initiation phase. Treatment intervals adjusted according to individual patient response. Aflibercept HDq16 Aflibercept High Dose VEGF Trap-Eye (BAY86-5321) Aflibercept high dose administered every 16 weeks after an initiation phase. Treatment intervals adjusted according to individual patient response.
- Primary Outcome Measures
Name Time Method Change From Baseline in BCVA Measured by the ETDRS Letter Score at Week 48 At baseline and Week 48 Visual function of the study eye was assessed at a distance of 4 meters using the ETDRS BCVA letter score. BCVA scale range is 0 (worst) to 100 (best).
- Secondary Outcome Measures
Name Time Method Percentage of Participants With no Intraretinal Fluid (IRF) and no Subretinal Fluid (SRF) in Central Subfield at Week 16 At Week 16 Percentage of Participants With no Intraretinal Fluid (IRF) and no Subretinal Fluid (SRF) in the Center Subfield at Week 48 At Week 48 Percentage of Participants Achieving an ETDRS Letter Score of at Least 69 (Approximate 20/40 Snellen Equivalent) at Week 48 At Week 48 Change in Total Lesion Area From Baseline to Week 48 At baseline and Week 48 Change From Baseline in Central Subfield Retinal Thickness (CST) at Week 48 At baseline and Week 48 Change From Baseline in BCVA Measured by the ETDRS Letter Score at Week 60 At baseline and Week 60 Visual function of the study eye was assessed at a distance of 4 meters using the ETDRS BCVA letter score. BCVA scale range is 0 (worst) to 100 (best).
Number of Participants With Treatment-emergent Adverse Events (TEAEs) and Serious AEs (SAEs) Up to 156 weeks Percentage of Participants Gaining at Least 15 Letters in BCVA From Baseline at Week 48 At baseline and Week 48 Change in Choroidal Neovascularization (CNV) Size From Baseline to Week 48 At baseline and Week 48 Change From Baseline in National Eye Institute Visual Functioning Questionnaire-25 (NEI-VFQ-25) Total Score at Week 48 At baseline and Week 48 NEI VFQ-25 was a 25-item questionnaire that gave a score on a scale from 0 (worst) to 100 (best = no vision problems)
Systemic Exposure to Aflibercept as Assessed by Plasma Concentrations of Free, Adjusted Bound and Total Aflibercept From Baseline Through Week 48 Up to Week 48 Assessment of Immunogenicity to Aflibercept by Measuring the Incidence of Treatment-emergent Anti-drug Antibodies (ADA) Response Through End of Masked Study Up to week 96
Trial Locations
- Locations (235)
SEHAT Pentagram
🇧🇬Sofia, Bulgaria
University Multiprofile Hospital For Active Treatment 'Alexandrovska' EAD
🇧🇬Sofia, Bulgaria
Arizona Retina and Vitreous Consultants - North Phoenix
🇺🇸Phoenix, Arizona, United States
Retina Consultants of Orange County
🇺🇸Fullerton, California, United States
University of California San Diego (UCSD)
🇺🇸La Jolla, California, United States
Northern California Retina-Vitreous Associates
🇺🇸Mountain View, California, United States
California Eye Specialists Medical Group, Inc.
🇺🇸Pasadena, California, United States
Retina Consultants San Diego
🇺🇸Poway, California, United States
Retina Consultants of Southern California
🇺🇸Redlands, California, United States
Kaiser Permanente Riverside Medical Center
🇺🇸Riverside, California, United States
Retina Consultants of Southern Colorado, PC
🇺🇸Colorado Springs, Colorado, United States
New England Retina Associates
🇺🇸New London, Connecticut, United States
Rand Eye Institute
🇺🇸Deerfield Beach, Florida, United States
Retina Group of Florida - Fort Lauderdale
🇺🇸Fort Lauderdale, Florida, United States
Vitreo Retinal Associates PA - The Millennium Center Location
🇺🇸Gainesville, Florida, United States
Florida Retina Institute- Jacksonville Oak
🇺🇸Jacksonville, Florida, United States
Florida Eye Associates
🇺🇸Melbourne, Florida, United States
Retina Macula Specialists Of Miami
🇺🇸Miami, Florida, United States
Florida Retina Institute
🇺🇸Orlando, Florida, United States
Spec. Hosp. for Active Treatment for Eye Diseases Zrenie
🇧🇬Sofia, Bulgaria
Retina Specialists
🇺🇸Pensacola, Florida, United States
Retina Vitreous Associates of Florida - Saint Petersburg
🇺🇸Saint Petersburg, Florida, United States
Southern Vitreoretinal Associates, P.L. - Tallahassee
🇺🇸Tallahassee, Florida, United States
Retina Consultants of Hawaii
🇺🇸'Aiea, Hawaii, United States
Retina Associates IL
🇺🇸Elmhurst, Illinois, United States
University Retina and Macula Associates
🇺🇸Oak Forest, Illinois, United States
Wolfe Eye Clinic - Des Moines
🇺🇸West Des Moines, Iowa, United States
Retina Care Center
🇺🇸Baltimore, Maryland, United States
Ophthalmic Consultants of Boston (OCB) - Boston
🇺🇸Boston, Massachusetts, United States
Vitreo Retinal Surgery PA - Edina
🇺🇸Edina, Minnesota, United States
Retina Consultants of Nevada
🇺🇸Las Vegas, Nevada, United States
Retina Center of New Jersey
🇺🇸Bloomfield, New Jersey, United States
NJ Retina - Edison Office
🇺🇸Edison, New Jersey, United States
Eye Associates of New Mexico
🇺🇸Albuquerque, New Mexico, United States
Long Island Vitreoretinal Consultants
🇺🇸Great Neck, New York, United States
Long Island Vitreoretinal Consultants - Hauppauge
🇺🇸Hauppauge, New York, United States
Ophthalmic Consultants of Long Island
🇺🇸Lynbrook, New York, United States
Ophthalmic Consultants of the Capital Region
🇺🇸Troy, New York, United States
Wake Forest Baptist Health
🇺🇸Winston-Salem, North Carolina, United States
Midwest Retina - Main Office
🇺🇸Dublin, Ohio, United States
Retina Northwest, PC - Opthalmology
🇺🇸Portland, Oregon, United States
Retina Consultants, LLC
🇺🇸Salem, Oregon, United States
Mid Atlantic Retina
🇺🇸Bethlehem, Pennsylvania, United States
Erie Retinal Surgery, Inc.
🇺🇸Erie, Pennsylvania, United States
Eye Care Specialists
🇺🇸Kingston, Pennsylvania, United States
Charleston Neuroscience Institute - Charleston
🇺🇸Charleston, South Carolina, United States
Palmetto Retina Center (PRC)- West Columbia Retina Center
🇺🇸West Columbia, South Carolina, United States
Black Hills Regional Eye Institute
🇺🇸Rapid City, South Dakota, United States
Charles Retina Institute
🇺🇸Memphis, Tennessee, United States
Vanderbilt University Medical School
🇺🇸Nashville, Tennessee, United States
Austin Retina Associates
🇺🇸Austin, Texas, United States
Texas Retina Associates
🇺🇸Fort Worth, Texas, United States
Medical Center Ophthalmology Associates
🇺🇸San Antonio, Texas, United States
Retinal Consultants of Texas - San Antonio
🇺🇸San Antonio, Texas, United States
Retina Consultants of Texas (Retina Consultants of Houston) - Texas Medical Center
🇺🇸The Woodlands, Texas, United States
Retina Consultants of Texas - The Woodlands
🇺🇸The Woodlands, Texas, United States
The University of Vermont Medical Center (Fletcher Allen Health Care) - Main Campus
🇺🇸Burlington, Vermont, United States
Spokane Eye Clinical Research
🇺🇸Spokane, Washington, United States
West Virginia University
🇺🇸Morgantown, West Virginia, United States
University of Wisconsin - Madison
🇺🇸Madison, Wisconsin, United States
Organizacion Medica de Investigacion (OMI)
🇦🇷Buenos Aires, Ciudad Auton. De Buenos Aires, Argentina
OFTALMOS, Instituto Oftalmologico de Alta Complejidad
🇦🇷Buenos Aires, Ciudad Auton. De Buenos Aires, Argentina
Eyeclinic Albury Wodonga
🇦🇺Albury, New South Wales, Australia
Sydney Retina Clinic
🇦🇺Sydney, New South Wales, Australia
Westmead Hospital
🇦🇺Westmead, New South Wales, Australia
Hobart Eye Surgeons
🇦🇺Hobart, Tasmania, Australia
Marsden Eye Surgery Center
🇦🇺Parramatta, Australia
Klinikum Klagenfurt am Wörthersee
🇦🇹Klagenfurt, Kärnten, Austria
Kepler Universitätsklinikum Campus III
🇦🇹Linz, Oberösterreich, Austria
Konventhospital Barmherzige Brüder Linz
🇦🇹Linz, Oberösterreich, Austria
Medizinische Universität Graz
🇦🇹Graz, Steiermark, Austria
Hanusch-Krankenhaus Wien
🇦🇹Wien, Austria
Multiprofile Hospital for Active Treatment Sveta Sofia | Internal Diseases Department
🇧🇬Sofia, Bulgaria
Specialized Hospital For Active Treatment of Eye Diseases Zora
🇧🇬Sofia, Bulgaria
Sveta Petka Eye Hospital
🇧🇬Varna, Bulgaria
St.Joseph's Health Care-London
🇨🇦London, Ontario, Canada
Toronto Retina Institute
🇨🇦Toronto, Ontario, Canada
Institut de l'Oeil des Laurentides
🇨🇦Boisbriand, Quebec, Canada
The Second Hospital of Anhui medical university
🇨🇳Hefei, Anhui, China
Beijing Tongren Hospital, Capital Medical University (East)
🇨🇳Beijing, Dongcheng District, China
The 1st Affiliated Hospital Fujian Medical University
🇨🇳Fuzhou, Fujian, China
Guangzhou Aier Eye Hospital
🇨🇳Guangzhou, Guangdong, China
Hebei eye hospital
🇨🇳Hebei, Hebei, China
Shijiazhuang General Hospital
🇨🇳Shijiazhuang, Hebei, China
Henan Provincial Eye Hospital
🇨🇳Henan, Henan, China
Tongji Hosp. of Tongji Med Coll, Huazhong Uni of Sci & Tech.
🇨🇳Wuhan, Hubei, China
Union Hospt Tongji Medical Colleg. Huazhong univ. Scien&Tech
🇨🇳Wuhan, Hubei, China
The First People's Hospital of Xuzhou
🇨🇳Xuzhou, Jiangsu, China
Jiangxi Provincial People's Hospital
🇨🇳Nanchang, Jiangxi, China
The First Affiliated Hospital of NanChang University
🇨🇳Nanchang, Jiangxi, China
Eye Center of the second Bethune Hospital, jinlin University
🇨🇳Changchun, Jilin, China
Tonghua Central Hospital
🇨🇳Tonghua, Jilin, China
Shenyang He Eye Specialist Hospital
🇨🇳Shenyang, Liaoning, China
People's Hospital of Ningxia Hui Autonomous Region - Opthalmology
🇨🇳Ningxia, Ningxia, China
The First Affiliated Hospital of Xi'an Jiaotong University
🇨🇳Xi'an, Shanxi, China
Aier Eye Hospital (Chengdu)
🇨🇳Chengdu, Sichuan, China
The First Affiliated Hospital of Xinjiang Medical University
🇨🇳Urumqi, Xinjiang, China
The 1st Affiliated Hospital of Zhejiang University
🇨🇳Hangzhou, Zhejiang, China
ZheJiang Provincial People's Hospital
🇨🇳Hangzhou, Zhejiang, China
Clinical hospital center Zvezdara
🇷🇸Belgrade, Serbia
The Affiliated Eye Hospital of Wenzhou Medical College
🇨🇳Wenzhou, Zhejiang, China
Beijing Aier Intech Eye Hospital
🇨🇳Beijing, China
Peking University People's Hospital
🇨🇳Beijing, China
Beijing Hospital
🇨🇳Beijing, China
Chongqing Aier Ophthalmology Hospital
🇨🇳Chongqing, China
Shanghai Tongji Hospital of Tongji University
🇨🇳Shanghai, China
Shanghai General Hospital
🇨🇳Shanghai, China
Tianjin Medical University General Hospital
🇨🇳Tianjin, China
Tianjin Eye Hospital
🇨🇳Tianjin, China
Tianjin Medical University Eye Hospital
🇨🇳Tianjin, China
Fakultni Nemocnice Hradec Kralove
🇨🇿Hradec Kralove, Czechia
Fakultni nemocnice Ostrava
🇨🇿Ostrava, Czechia
Fakultni nemocnice Plzen - Lochotin
🇨🇿Plzen-Lochotin, Czechia
Charles University in Prague
🇨🇿Prague, Czechia
Fakultni nemocnice Kralovske Vinohrady
🇨🇿Praha 10, Czechia
Lexum a.s., Evropska ocni klinika
🇨🇿Praha 4, Czechia
AXON Clinical s.r.o.
🇨🇿Praha 5, Czechia
East Tallinn Central Hospital
🇪🇪Tallinn, Estonia
Tartu University Hospital
🇪🇪Tartu, Estonia
Centre d'Ophtalmologie - Paradis-Monticelli
🇫🇷Marseille, France
Hôpital Lariboisière - Paris
🇫🇷Paris, France
Centre ophtalmologique Saint-Exupéry
🇫🇷Saint-Cyr-Sur-Loire, France
LTD "Clinic LJ" - Opthalmology
🇬🇪Kutaisi, Georgia
JSC "Evex Hospitals'
🇬🇪Tbilisi, Georgia
LTD "Innova"
🇬🇪Tbilisi, Georgia
LTD "Chichua Medical Center MZERA"
🇬🇪Tbilisi, Georgia
Budapest Retina Associates
🇭🇺Budapest, Hungary
Szent-Gyorgyi Albert Orvostudomanyi Egyetem
🇭🇺Szeged, Hungary
Rambam Health Corporation
🇮🇱Haifa, Israel
Lady Davis Carmel Medical Center
🇮🇱Haifa, Israel
Hadassah Hebrew University Hospital Ein Kerem
🇮🇱Jerusalem, Israel
Meir Medical Center
🇮🇱Kfar Saba, Israel
Chaim Sheba Medical Center
🇮🇱Ramat Gan, Israel
Kaplan Medical Center
🇮🇱Rehovot, Israel
Assuta Medical Centers - HaShalom
🇮🇱Tel Aviv, Israel
Fondazione PTV Policlinico Tor Vergata
🇮🇹Roma, Lazio, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
🇮🇹Roma, Lazio, Italy
IRCCS Fondazione G.B. Bietti Studio e Ricerca in Otalmologia
🇮🇹Roma, Lazio, Italy
ASST Fatebenefratelli Sacco
🇮🇹Milano, Lombardia, Italy
Ospedale San Raffaele s.r.l. - Oculistica
🇮🇹Milano, Lombardia, Italy
A.O.U. di Cagliari
🇮🇹Cagliari, Sardegna, Italy
A.O. di Perugia
🇮🇹Perugia, Umbria, Italy
Daiyukai Daiichi Hospital
🇯🇵Ichinomiya, Aichi, Japan
Aichi Medical University Hospital
🇯🇵Nagakute, Aichi, Japan
Nagoya University Hospital
🇯🇵Nagoya, Aichi, Japan
Nagoya City University Hospital
🇯🇵Nagoya, Aichi, Japan
Kokura Memorial Hospital
🇯🇵Kitakyushu, Fukuoka, Japan
Kurume University Hospital
🇯🇵Kurume, Fukuoka, Japan
Southern Tohoku Eye Clinic
🇯🇵Koriyama, Fukushima, Japan
Gunma University Hospital
🇯🇵Maebashi, Gunma, Japan
Sapporo City General Hospital
🇯🇵Sapporo, Hokkaido, Japan
KKR Sapporo Medical Center
🇯🇵Sapporo, Hokkaido, Japan
Hyogo Prefectural Amagasaki General Medical Center
🇯🇵Amagasaki, Hyogo, Japan
Kobe University Hospital
🇯🇵Kobe, Hyogo, Japan
Kozawa Eye Hospital and Diabetes Center
🇯🇵Mito, Ibaraki, Japan
Kanazawa Medical University Hospital
🇯🇵Kahoku-gun, Ishikawa, Japan
Kanazawa University Hospital
🇯🇵Kanazawa, Ishikawa, Japan
Kagawa University Hospital
🇯🇵Kita-gun, Kagawa, Japan
Medical corporation Eiwakai Dannoue Ophthalmology clinic
🇯🇵Kawasaki, Kanagawa, Japan
St. Marianna University Hospital
🇯🇵Kawasaki, Kanagawa, Japan
Otakeganka Tsukimino Clinic
🇯🇵Yamato, Kanagawa, Japan
Mie University Hospital
🇯🇵Tsu, Mie, Japan
Shinshu University Hospital
🇯🇵Matsumoto, Nagano, Japan
Nara Medical University Hospital
🇯🇵Kashihara, Nara, Japan
Oita University Hospital
🇯🇵Yufu, Oita, Japan
Kurashiki Medical Center
🇯🇵Kurashiki, Okayama, Japan
Okayama University Hospital
🇯🇵Okayama-city, Okayama, Japan
University of the Ryukyus Hospital
🇯🇵Nakagami, Okinawa, Japan
Kansai Medical University Hospital
🇯🇵Hirakata, Osaka, Japan
Kansai Medical University Medical Center
🇯🇵Moriguchi, Osaka, Japan
Kindai University Hospital
🇯🇵Osakasayama-shi, Osaka, Japan
The University of Tokyo Hospital
🇯🇵Bunkyo-ku, Tokyo, Japan
St.Luke's International Hospital
🇯🇵Chuoku, Tokyo, Japan
Nishikasai Inouye Eye Hospital
🇯🇵Edogawa-ku, Tokyo, Japan
Tokyo Medical University Hachioji Medical Center
🇯🇵Hachioji, Tokyo, Japan
Tokiwadai Muranaka Eye Clinic
🇯🇵Itabashi-ku, Tokyo, Japan
National Hospital Organization Tokyo Medical Center
🇯🇵Meguro-ku, Tokyo, Japan
Keio University Hospital
🇯🇵Shinjuku-ku, Tokyo, Japan
Tokyo Women's Medical University Hospital
🇯🇵Shinjuku-ku, Tokyo, Japan
Yamaguchi University Hospital
🇯🇵Ube, Yamaguchi, Japan
University of Yamanashi Hospital
🇯🇵Chuo, Yamanashi, Japan
Akita University Hospital
🇯🇵Akita, Japan
Hayashi Eye Hospital
🇯🇵Fukuoka, Japan
Klinicki centar Vojvodine
🇷🇸Novi Sad, Serbia
Fukushima Medical University Hospital
🇯🇵Fukushima, Japan
Hiroshima University Hospital
🇯🇵Hiroshima, Japan
University of Miyazaki Hospital
🇯🇵Miyazaki, Japan
Japanese Red Cross Nagasaki Genbaku Hospital
🇯🇵Nagasaki, Japan
Japanese Red Cross Saitama Hospital
🇯🇵Saitama, Japan
Tokushima University Hospital
🇯🇵Tokushima, Japan
Japanese Red Cross Wakayama Medical center
🇯🇵Wakayama, Japan
Yamagata University Hospital
🇯🇵Yamagata, Japan
Nune Eye Hospital - Retina Center Ophthalmology
🇰🇷Seoul, Gangnam-gu, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam-si, Gyeonggido, Korea, Republic of
Pusan National University Hospital
🇰🇷Busan, Korea, Republic of
Inje University Haeundae Paik Hospital
🇰🇷Busan, Korea, Republic of
Seoul National University Hospital (b)
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Department of Ophthalmology
🇱🇻Riga, Latvia
Latvian American Eye Center
🇱🇻Riga, Latvia
Riga East Clinical University Hospital "Gailezers"
🇱🇻Riga, Latvia
Hospital of LT University of Health Sciences Kaunas Clinics
🇱🇹Kaunas, Lithuania
PI Klaipedos University Hospital
🇱🇹Klaipeda, Lithuania
Vilnius University Hospital Santaros Klinikos
🇱🇹Vilnius, Lithuania
ALM Oftalmolaser - Oftalmologia Medica e Cirurgica
🇵🇹Lisbon, Lisboa, Portugal
AIBILI
🇵🇹Coimbra, Portugal
Espaco Medico de Coimbra
🇵🇹Coimbra, Portugal
Centro Hospitalar Universitario do Porto
🇵🇹Porto, Portugal
Centro Hospitalar Vila Nova de Gaia e Espinho | Unit 1 - Clinical Research Center
🇵🇹Porto, Portugal
Scientific Research Institution of Ophthalmic Diseases
🇷🇺Moscow, Russian Federation
FBSI IRTC Eye Microsurgery n.a. acad. S.N. Fyodorov
🇷🇺Moscow, Russian Federation
Clinical Center of Serbia
🇷🇸Belgrade, Serbia
National University Hospital
🇸🇬Singapore, Singapore
Singapore National Eye Centre
🇸🇬Singapore, Singapore
Fakultna nemocnica Nitra
🇸🇰Nitra, Slovakia
Nemocnica s Poliklinikou Trebisov, Svet zdravia a.s.
🇸🇰Trebisov, Slovakia
Fakultna nemocnica Trencin
🇸🇰Trencin, Slovakia
Fakultna nemocnica s poliklinikou Zilina
🇸🇰Zilina, Slovakia
Instituto Oftalmológico Francisco Gomez Ulla
🇪🇸Santiago de Compostela, A Coruña, Spain
Hospital Clínic i Provincial de Barcelona
🇪🇸Barcelona, Spain
Hospital de la Santa Creu i Sant Pau | Gynecology Department
🇪🇸Barcelona, Spain
Hospital Reina Sofía
🇪🇸Córdoba, Spain
Hospital General Universitario de Valencia
🇪🇸Valencia, Spain
La Fe University and Polytechnic Hospital | Nephrology Department
🇪🇸Valencia, Spain
Hospital Miguel Servet
🇪🇸Zaragoza, Spain
RétinElysée
🇨🇭Lausanne, Vaud, Switzerland
Berner Augenklinik am Lindenhofspital
🇨🇭Bern, Switzerland
Stadtspital Triemli
🇨🇭Zürich, Switzerland
Shin Kong Wu Ho-Su Memorial Hospital
🇨🇳Taipei, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Chang Gung Memorial Hospital at Linkou
🇨🇳Taoyuan, Taiwan
Private enterprise private production company " Acinus"
🇺🇦Kropyvnytskyi, Ukraine
Centralna Polyclinica MVS Ukraiiny
🇺🇦Kyiv, Ukraine
Poltava Regional Clinical Hospital n.a. M.V. Skliphosovskyi
🇺🇦Poltava, Ukraine