EXtended use of FOsfomycin for the treatment of CYstitis in primary care

MC Utrecht0 个研究点目标入组 777 人开始时间: 待定最近更新: 2024年6月11日

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•Adult women (>18 years of age) with a diagnosis of uncomplicated cystitis in primary care
•-Cystitis diagnosis is according to the flow diagram in the Dutch NHG-guideline. In line with the NHG guideline 2020, recognition of symptoms should always be accompanied with either a positive nitrite test or leucocyte and dipslide test
•-Urine collection is performed according to the Dutch NHG-guideline

•-Presence of signs of tissue invasion according to NHG guideline: fever, malaise, chills, flank or perineal pain, signs of sepsis or delirium
•-Pregnancy or nursing*
•-Diabetes Mellitus
•-Immunocompromised state:
•oUntreated infection with human immunodeficiency virus (hiv)
•oUse of high-dose systemic corticosteroids
•oUse of other immunosuppressive medication
•-Presence of an indwelling urinary catheter
•-History of abnormalities in urinary tract or kidneys
•-Neurogenic bladder dysfunction
•-UTI in past 28 days before inclusion
•-Antibiotic prophylaxis (current or in past 28 days)with nitrofurantoin or fosfomycin or trimethoprim.
•-Known GFR <30mL/min
•-Contra-indication for nitrofurantoin or fosfomycin use (e.g. allergic reactions, lung or liver reaction or peripheral neuropathy after previous use in clinical history, acute porphyria, G6PD deficiency)
•-Current use of an antibiotic for any reason
•-Previous inclusion in EXFOCY
•-Presence of urine cultures showing resistance for nitrofurantoin or fosfomycin in the last 12 months

发起方

MC Utrecht