EXtended use of FOsfomycin for the treatment of CYstitis in primary care - EXFOCY

niversity Medical Center Utrecht0 个研究点目标入组 741 人开始时间: 2021年4月24日最近更新: 2021年7月12日

试验速览

暂无简介。

•-Adult women (>18 years of age) with a diagnosis of uncomplicated cystitis in primary care
•-Cystitis diagnosis is according to the flow diagram in the Dutch NHG-guideline. In line with the NHG guideline 2020, recognition of symptoms should always be accompanied with either a positive nitrite test or leucocyte and dipslide test
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 500
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 241

•-Pregnancy
•-Diabetes Mellitus
•-Immunocompromised state
•oUntreated infection with human immunodeficiency virus (hiv)
•oUse of high-dose systemic corticosteroids
•oUse of other immunosuppressive medication (specified in protocol)
•-Presence of an indwelling urinary catheter
•-History of abnormalities in urinary tract or kidneys
•-Neurogenic bladder dysfunction
•-UTI in past 28 days before inclusion
•-Antibiotic prophylaxis in past 28 days with nitrofurantoin or fosfomycin
•-Known GFR <30mL/min
•-Contra-indication for nitrofurantoin or fosfomycin use (e.g. allergic reactions, lung or liver reaction or peripheral neuropathy after previous use in clinical history, acute porphyria, G6PD deficiency)
•-Current use of an antibiotic for any reason

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