Integrative Proteomic Characterization of Pancreatic Ductal Adenocarcinoma
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Integrative Proteomic Characterization of PDAC
研究概览
简要总结
A large-scale, high-throughput, multi-dimensional comprehensive study of PDAC multiomics will be carried out. In this study, clinical specimens of resected PDAC collected by our research group from 2017 to 2019 will be selected as research objects.Tumor tissues and their adjacent non-tumor tissues from more than 200 PDAC patients are expected to be used for genome, transcriptome sequencing and mass spectrometry analysis of proteome and phosphorylated proteome.Combined with the data results of multiomics, bioinformatics analysis and network database information, we will clarify the relationship between multiomics of pancreatic cancer and established the new subtyping of pancreatic cancer proteome. A molecular landscape of the progression of pancreatic cancer at the genome-transcriptome-proteome level provides new therapeutic targets to improve the prognosis of this deadly disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The diagnosis of pancreatic cancer was confirmed by histological examination or fine needle aspiration cytology;
- •The tumor was graded according to THE WHO standard, and the tumor stage was graded according to the TNM stage;
排除标准
- •The inclusion criteria of the above groups were not met;
- •There are few tissue specimens, only enough for clinical diagnosis;
- •Patients are unwilling to conduct follow-up study;
- •For the new diagnosed patient, radiotherapy or chemotherapy have been given in the previous three months;
结局指标
主要结局
Integrative Proteomic Characterization of PDAC
时间窗: Two yeaers
The genome-transcriptome proteome level provides a molecular landscape of the progression of pancreatic cancer, providing new therapeutic targets to improve the prognosis of PDAC
次要结局
未报告次要终点