Effect of intra-lipid in methadone toxicity

Phase 3

Recruiting

• Conditions: Poisoning by narcotics and psychodysleptics [hallucinogens]: Methadone.; Poisoning by, adverse effect of and underdosing of methadone; T40.3

• Registration Number: IRCT20201220049774N2
• Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 7 February 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 82

Inclusion Criteria

Giving informed consent

Exclusion Criteria

History of pancreatitis with hyperlipidemia
Known allergies eggs or soy proteins
History of severe hyperlipidemia (serum triglyceride concentration greater than 1000 mg / dl)
Acute shock
History of severe hepatic impairment (child pugh class C)
Acute heart attack
Non-opioid poisoning
Cerebrovascular events
Taking other drugs that increase the QT interval

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
umber of breaths per minute. Timepoint: From before intervention to 5 hours after it per one hour. Method of measurement: Cardiac monitoring device.

Secondary Outcome Measures

Name	Time	Method
QT intervale. Timepoint: From before intervention to 5 hours after it hourly. Method of measurement: Cardiac monitoring device.;Systolic, diastolic and mean arterial blood pressure. Timepoint: From before intervention to 5 hours after it hourly. Method of measurement: Cardiac monitoring device.;Shortness of breath, cyanosis and pupil size. Timepoint: From before intervention to 5 hours after it hourly. Method of measurement: Physical examination.;Blood oxygen concentration level. Timepoint: From before intervention to 5 hours after it hourly. Method of measurement: Cardiac monitoring device.;Level of consciousness. Timepoint: From before intervention to 5 hours after it hourly. Method of measurement: Glosgow coma scale.;Heart rate. Timepoint: From before intervention to 5 hours after it hourly. Method of measurement: Cardiac monitoring device.;Number of times naloxone is prescribed. Timepoint: 5 hours after intervention. Method of measurement: Patient nursing care cardex.