The effect of intraileal infusion of fat emulsions, differing in degree of saturation, on satiety and food intake after a liquid meal replacement.
Completed
- Conditions
- Obesity.
- Registration Number
- NL-OMON23841
- Lead Sponsor
- MC - Dept of Gastroenterology - HepatologyPO box 96002300 RC Leidenfax nr.:0715248115tel. nr.:0715263507
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 15
Inclusion Criteria
1. Signed informed consent form;
2. Sex: male or female;
Exclusion Criteria
1. Evidence of severe cardiovascular, respiratory, urogenital, gastrointestinal/ hepatic, hematological/immunologic, HEENT (head, ears, eyes, nose, throat), dermatological/connective tissue, musculoskeletal, metabolic/nutritional, endocrine, neurological/psychiatric diseases, allergy, major surgery and/or laboratory assessments which might limit participation in or completion of the study protocol;
2. Gastrointestinal or hepatic disorders influencing gastrointestinal absorption or transit;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess whether emulsions differing in degree of saturation, have different effects when administered in the ileum, on satiety as measured by visual analogue scales, and food intake during ad libitum lunch.
- Secondary Outcome Measures
Name Time Method To assess the effect of emulsions differing in degree of saturation, when infused in the ileum on gastric emptying, intestinal transit time and on secretion of peptides known to affect satiety. <br />Peptides we will measure are Ghrelin and CCK as proximal gut hormones and Apo A-IV and PYY as distal gut hormones (ileal brake).