Intermittent Versus Continuous Enteral Nutrition in Mechanically Ventilated Patients in the Medical Intensive Care Unit

Not Applicable

• Conditions: Enteral Feeding; Nutrition Disorders
• Interventions: Dietary Supplement: Intermittent feed participant; Dietary Supplement: Continuous feeds participant

• Registration Number: NCT04437264
• Lead Sponsor: Yale University

Brief Summary

Evaluate effective delivery of goal nutrition with intermittent as compared with continuous enteral nutrition schedules, as defined by percentage of recommended calories that patient receives per day of interest.

Detailed Description

Eligible patients will be approached and if the patient (or surrogate decision maker) is interested, then consent will be obtained for participation in the study. The patient will then be randomly assigned to receive usual care (continuous feeds) or intervention (intermittent feeds, see details below). Randomization will occur via simple block randomization within the REDCap software. Group assignment will not be revealed to the clinical team until the decision to feed the patient has occurred and the actual feeding order is entered. When the clinical team decides to initiate enteral nutrition, they will place a nutrition consult order for tube feed recommendations. Nutrition consult will place recommendations for both continuous feeding and for intermittent schedule, including enteral nutrition formula and dosing. Prior to feeds being started, the patient's randomization status will be revealed to the clinical team. The covering provider will then place the order for enteral nutrition according to the nutritionist's recommendations for the correct feeding schedule.

For patients randomized to continuous feeds, their enteral nutrition will be ordered and delivered as per usual care and standard MICU procedure. Nutritionist will provide recommendations for initiation rate, up titration schedule, and maintenance dosing to be delivered continuously over 24 hours. Under usual care of ICU patients, our clinical nutritionists provide a specified formula, a specified calorie goal, and a suggested titration rate. This is typically 20 mL per hour to start with an increase in rate of 20 mL per hour every 6 to 8 hours until the goal rate is achieved. Typical goal rates are in the range of 60 to 80 mL per hour for 24 hours per day.

For patients randomized to the intervention group (intermittent feeds), they will receive their enteral nutrition according to a research protocol schedule. This will involve the total recommended feed volume divided into four equal volume "meals." These will be delivered at a rate of 400 cc/hr at 8:00, 12:00, 16:00, and 20:00. The up-titration schedule will be as follows: first meal will be 100 mL, and the volume of each meal thereafter will be increased by 100mL until patient is at goal volume (typically between 300 and 450 mL). There are no formula or diets that are inappropriate to be administered on an intermittent feed schedule. The intervention will not change formula selection or total calorie goals. It will only change the schedule of feeding. For all patients, regardless of feeding schedule, the Kangaroo E-Pump will be used to deliver enteral nutrition, and the above rate and volume parameters can be programmed in.

There will be no change in delivery of enteral free water or medications. This schedule will be determined by nursing and clinical care team, as is the current standard of care. To assure correct ordering of intermittent feeds and the insulin prior to each meal, an EPIC orderset with prepopulated instructions will be developed.

If there are no signs of or clinical concerns for intolerance, patients will continue to receive enteral nutrition according to assigned schedule until they are extubated or until enteral nutrition is discontinued.

Study Timeline

• Study First Submitted: 2020-05-19
• Study First Submitted QC: 2020-06-15
• Study First Posted: 2020-06-18
• Study Start: 2020-07-07
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-02
• Last Update Posted: 2024-04-04
• Primary Completion: 2024-12
• Study Completion: 2024-12

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Not provided

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Exclusion Criteria

• At risk of refeeding syndrome.
• Pregnant patients.
• Patients receiving neuromuscular blockade.
• Patients with glycemic emergency (HHNK, DKA, severe hypoglycemia resulting in MICU admission) or patients controlling their sugar / insulin dosing via continuous glucose monitoring
• Post cardiac arrest (on current admission).
• Received >= 6 hours of enteral nutrition (regardless of volume) at the time of screening and team is able to consent / enroll / initiate intermittent feed within an additional 2 hours.
• Plan for extubation within 24 hours.
• Not English-speaking.
• Patients otherwise excluded by the treating physician.
• Retrospective exclusion: patients who initially met eligibility criteria, but no nutrition consult (i.e., decision to initiate feeds by clinical providers) placed within 72 hours of intubation.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Intermittent feed	Intermittent feed participant	Patients will be assigned to receive intermittent enteral feeding protocol. They will receive four equal volume feeds at 8:00, 12:00, 16:00, and 20:00 hours.
Continuous feeds	Continuous feeds participant	Patients will be assigned to receive continuous enteral feeding protocol. Typical goal rates are in the range of 60 to 80 mL per hour for 24 hours per day.

Primary Outcome Measures

Name	Time	Method
Recommended calories	Intubation day 1 to intubation day 10	percentage of recommended calories that patient receives per day of interest during study period

Secondary Outcome Measures

Name	Time	Method
urine 6-sulfatoxymelatonin acrophase	day 1 to 3 following initiation of feeds	Urine 6-sulfatoxymelatonin acrophase defined as the time of fitted peak 6-sulfatoxymelatonin from fitting a cosine curve to hourly urine aMT6s levels will be determined daily
minimum glucose	Intubation day 1 to intubation day 10	lowest glucose per day of interest
feasibility: proportion complete protocol	Intubation day 1 to intubation day 10	percentage of patients assigned to intervention (ie intermittent feeding protocol) that remain on study protocol for study period of interest.
maximum glucose	Intubation day 1 to intubation day 10	highest glucose per day of interest
insulin usage	Intubation day 1 to intubation day 10	number of insulin units used per day (composite of short and long acting formulations)
Percentage of patients with aspiration	Intubation day 1 to intubation day 10	percentage of patients experiencing aspiration
Percentage of patients experiencing intolerance of feeding	Intubation day 1 to intubation day 10	percentage of patients experiencing intolerance of feeding including nausea, vomiting, diarrhea, ileus
delirium	intubation day 1 until 14 days later	number of delirium and coma free days out of 14 following intubation

Trial Locations

Locations (1)

Yale New Haven Hospital, York Street Campus; 🇺🇸 New Haven, Connecticut, United States