Investigating the efficacy of early vs. late primaquine treatment for children with uncomplicated malaria due to infection with either Plasmodium vivax or Plasmodium falciparum

Phase 4

Suspended

• Conditions: Malaria; Infection - Other infectious diseases

• Registration Number: ACTRN12620000855921
• Lead Sponsor: The University of Western Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-08-27
• Last Update Posted: 31 August 2020

Recruitment & Eligibility

• Status: Suspended
• Sex: All
• Target Recruitment: 220

Inclusion Criteria

i) Children aged 0.5 to 12 years
ii) Axillary temperature >37.5 degrees Celcius (or self-reported fever during previous 24 hours)
iii) Positive for malaria by on-site microscopy, or rapid diagnostic test, or polymerase chain reaction
iv) Have not received a study intervention in the previous 4 weeks
v) They have no significant co-morbidity
vi) they can attend follow-up assessments over the full duration of the study.

Exclusion Criteria

i) Clinical signs or symptoms consistent with severe malaria
ii) History of allergy to artemether-lumefantrine or primaquine
iii) A proven history of G6PD deficiency
iv) Severe malnutrition
v) Haemoglobin <50 g/

Study & Design

• Study Type: Interventional
• Study Design: Not specified