Comparing three types of training to improve language function in people with language problems following a stroke

Not Applicable

Completed

• Conditions: Aphasia following stroke; Nervous System Diseases

• Registration Number: ISRCTN84827527
• Lead Sponsor: the First Affiliated Hospital with Nanjing Medical University

Brief Summary

2019 Results article in https://www.ncbi.nlm.nih.gov/pubmed/30762012 results

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2015-01-05
• Study Start: 2019-01-10
• Last Update Posted: 13 March 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Stroke patients with aphasia:
1. First occurrence of cerebral infarction or hemorrhage
2. Aged 35–70 years
3. Disease course lasting for 3–24 months
4. Right-handed according to the Edinburgh Handedness Inventory
5. Educated beyond primary school (more than 5 years of education)
6. Aphasia determined by Western Aphasia Battery (WAB) (aphasia quotient <93.8)
7. No obvious attention, memory, and visuo-spatial function disturbances (Non-language cognitive function assessment scale, 2013 >70)
8. Retaining part of the auditory ability and tolerance of more than 30 minutes to complete the daily training task

Healthy participants:
9. Right-handedness according to the Edinburgh Handedness Inventory
10. Aged 18–30 years
11. Over 12 years of education
12. Willing to participate in the experiment and able to tolerate the experiment

Exclusion Criteria

Stroke patients with aphasia:
1. Frenchay dysarthria assessment shows moderate to severe dysarthria
2. Serious speech apraxia or oral and maxillofacial apraxia
3. Anxiety determined by Hamilton Anxiety Scale or depression determined by Hamilton Depression Scale
4. Obvious dyssomnia or emotional disturbances
5. Other diseases likely to aggravate patient’s functional status such as cancer, severe heart or lung disease
6. Refused training or no desire for training
7. Severe pain, i.e. pain >8 out of 10 on a visual analog scale (VAS)

Healthy participants:
7. Poor physical condition for any reason
8. Refused training or no desire for training

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
anguage function assessed using the Western aphasia battery (WAB), including four sub-tests of oral language (i.e., spontaneous speech, auditory verbal comprehension, repetition, and naming) and aphasia quotient, before and after 2 weeks of training

Secondary Outcome Measures

Name	Time	Method
<br> 1. Naming of pictured objects. 180 pictures of objects selected from standardized picture naming norms in Mandarin were divided into three groups and used as the naming materials at 0 week (before treatment) and after 1 and 2 weeks of treatment.<br> 2. Naming of pictured actions. 120 pictures of actions were selected from the Russian language and neuropsychological research online database (http://neuroling.ru/en/analog.htm), divided into three groups and used as the naming materials at 0 week (before treatment) and after 1 and 2 weeks of treatment.<br> 3. Functional magnetic resonance imaging (fMRI) measurements. The fMRI experiment was carried out to investigate the influence of hand-action observation on language function and corresponding neurophysiology mechanism underlying MNS. This was done immediately after intervention.<br>