Clinic and Neurophysiology of Aphasia Treatment

Not Applicable

Not yet recruiting

• Conditions: Aphasia, Acquired
• Interventions: Behavioral: CIAT + Conventional neurorehabilitative therapy

• Registration Number: NCT05572385
• Lead Sponsor: Klinik Bavaria

Brief Summary

In the planned study, clinical and electrophysiological features of aphasia recovery in stroke patients are investigated.

Detailed Description

Clinical neurorehabilitation faces a major challenge of functional recovery in aphasia, i.e. guiding the structural and temporal dynamics of reorganization within responsible neural networks. Here, according to current research, relevant neural factors affecting the treatment and thus the functional recovery of aphasia patients after stroke are of interest, highlighting structural as well as functional neuroanatomical features. Of particular interest are not only the functional localization of affected cerebral regions, but more the clinical and neurophysiological patterns which might help to factorize and predict the therapeutic outcome. In the planned study, the clinical and neurophysiological characteristics of the dynamics of language function recovery in relation to the intensity of professional speech therapy (constraint induced aphasia therapie - CIAT) will be recorded in 40 patients with aphasia resulting from a cerebrovascular event. The aim of this study is to test the value of neurophysiological aspects based on electroencephalographic (EEG) parameters such as event-related potentials (N400, P600, theta band activity) for the identification of specific neuronal markers, which in turn support predictive statements for individual therapy planning of logopedic treatment in neurorehabilitation.

Study Timeline

• Status Verified: 2022-10
• Study First Submitted: 2022-10-04
• Study First Submitted QC: 2022-10-06
• Last Update Submitted: 2022-10-06
• Study First Posted: 2022-10-07
• Last Update Posted: 2022-10-07
• Study Start: 2023-07-01
• Primary Completion: 2025-12-31
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• patients with a cerebrovascular event

Exclusion Criteria

• premorbid brain disorder

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Patients with aphasia	CIAT + Conventional neurorehabilitative therapy	Patients with a clinical aphasia (20 receptive, 20 expressive) with a specific logopedic treatment, with specific EEG measurement at start and end of treatment schedule.

Primary Outcome Measures

Name	Time	Method
EEG correlates of language reconstitution	3-6 months after stroke	Identitification of EEG features (N400, P600, Theta band activity) that correlate with clinical outcome of language reconstitution.