The efficacy and safety of electroacupuncture in the treatment of Alzheimer's disease
- Conditions
- Alzheimer's disease
- Registration Number
- ITMCTR2100005087
- Lead Sponsor
- Guang'anmen Hospital, China Academy of Chinese Medicine Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
1. Meet the DSM-IV-R diagnostic criteria for dementia;
2. Meet the diagnostic criteria for probable AD in the NIA-AA criteria;
3. Aged 50 to 85 years;
4. Clinical dementia assessment score >= 0.5 points, MMSE score <= 26 points;
5. Hachinski ischemia scale score<=4 points;
6. It is allowed to have received ordinary acupuncture and electro-acupuncture before screening, but has not received electro-acupuncture in the past two weeks;
7. If the subject has the ability to make a decision, he/she shall sign the informed consent; if the patient's educational level is low and unable to sign the informed consent, the legal guardian shall sign the informed consent;
8. Caregivers or family members (guarantee to accompany the patient for >=3 hours a day, >=3 days a week) sign informed consent.
1. Accompanied by severe cerebrovascular disease;
2. Associated with other neurological or non-neurological diseases that can cause cognitive dysfunction or progressive memory impairment;
3. Drug-induced cognitive dysfunction or progressive memory impairment;
4. Inpatient or moderately high dependency nursing facility;
5. Patients with severe fear of needles, fainting of needles, and severe skin infections;
6. Patients with severe cardiovascular disease, malignant tumor, severe liver and kidney insufficiency;
7. Currently participating in other clinical trials.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinician Interview–Based Impression of Change scale;Neuropsychiatric Inventory;Alzheimer disease assessment scale cognition;
- Secondary Outcome Measures
Name Time Method Activity of Daily Living Scale;