Penetration and Compartimentation of HIV
Completed
- Conditions
- HIV
- Interventions
- Other: sample
- Registration Number
- NCT02513758
- Brief Summary
Genital mucosa is the main way of HIV penetration. Many cells can be involved (epithelial cells, Langerhans cells) and antibodies may also play a critical role. The investigators' study aims to precise the role of each type of cells, the interaction cell-cell and cell-antibodies.
- Detailed Description
At inclusion, men will have a two blood sampling tubes of 10 ml each, a saliva sample and a sample of sperm and women will have a two blood sampling tubes of 10 ml each, a saliva sample and a sampling cervicovaginal secretions
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
- Adults (> 18 year-old) HIV positive,
- HIV-CV> 1000 cp/ml,
Exclusion Criteria
- children
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description HIV patients sample Men will have blood sampling tubes of 10 ml each, a saliva sample and a sample of sperm Women will have a two blood sampling tubes of 10 ml each, a saliva sample and a sampling cervicovaginal secretions
- Primary Outcome Measures
Name Time Method Viral tropism of HIV Inclusion number of HIV virus in sperm or cervical secretions.
- Secondary Outcome Measures
Name Time Method Genetic polymorphism for HIV strains Inclusion With a sequencing method, it is possible to classify the different strains in groups, according to their polymorphism.
Trial Locations
- Locations (1)
LUCHT
🇫🇷Saint-etienne, France