Brain imaging in alcohol-responsive and alcohol-resistant essential tremor

Recruiting

• Conditions: essential tremor; trembling; 10028037

• Registration Number: NL-OMON53290
• Lead Sponsor: niversitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

- Diagnosis of essential tremor
- Age of 18 years or older

Exclusion Criteria

- Pregnancy
- History of (previous) alcohol misuse
- Medication incompatible with alcohol intake
- No alcohol consumption in the previous year
- MR contra-indications
For participants with essential tremor:
- (Very) mild tremor
For healthy participants:
- A first degree relative with essential tremor.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Tremor related brain activation will be investigated with EMG and<br /><br>accelerometry, as a measure for tremor, and fMRI, as a measure for brain<br /><br>activity.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters apart from EMG-fMRI:<br /><br>- Resting state fMRI<br /><br>- Task based fMRI (non-EMG)<br /><br>- Anatomical MRI<br /><br>Secondary study parameters related to measures of alcohol responsivity include:<br /><br>- Bain Findley Spirographs<br /><br>- Fahn-Tolosa-Marina Essential Tremor Rating Scale, part A, B and C, as a<br /><br>comprehensive measure of baseline tremor severity<br /><br>- Visual Analogue Scale, as a patient-based measure of tremor severity<br /><br>- Blood alcohol level measured with a breath analyser</p><br>