From the neurobiological basis of comorbid alcohol dependence and depression topsychological treatment strategies: bridging the knowledge gap

Not Applicable

Recruiting

Conditions: Comorbid alcohol dependence and depression
F10
F33
Mental and behavioural disorders due to use of alcohol
Recurrent depressive disorder

Registration Number: DRKS00010249

Lead Sponsor: Abteilung Klinische Psychologie, Zentralinstitut für Seelische Gesundheit, Medizinische Fakultät Mannheim/ Universität Heidelberg

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 120

Inclusion Criteria

1. Patients with alcohol abuse diagnosed according to DSM-5 criteria
2. Patients with depression diagnosed according to DSM-5 criteria
3.Patients with comorbid alcohol abuse and depression diagnosed according to DSM-5 criteria
4. Healthy controls as confirmed by SCID Interview

Exclusion Criteria

Exclusion criteria include psychiatric Axis I disorders (as measured by the SCID I interview) except for patients alcohol and nicotine abuse and depressive symptoms, neurological disorders, MRI specific criteria (pace maker or implanted metal), positive drug screening, at least 3 days without psychoactive medication before the first measurement, pregnancy and suicidal tendencies.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
eural correlates of reward and emotion processing in patients and healthy controls will be assessed at two time points by means of fMRI. While the first measurement (at baseline) will identify common and/or distinct neural signatures underlying the comorbidity of alcohol dependence and depression, the second measurement (after 6 weeks training) allows investigating the influence of the psychotherapeutic interventions on these target brain mechanisms. Consequently, in this study neural activation and connectivity in the reward system and default mode network are the primary outcome measures. <br>

Secondary Outcome Measures