ISRCTN66148745已完成4 期
A randomised, double-blind, placebo-controlled trial of metformin in chronic obstructive pulmonary disease (COPD) exacerbations: a pilot study evaluating anti-hyperglycaemic efficacy
St George's, University of London (UK)0 个研究点目标入组 69 人开始时间: 2011年3月17日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 69
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •Current inclusion criteria as of 06/03/2014:
- •1. Pre-existing diagnosis of COPD
- •2. Admission to hospital principally for an exacerbation of COPD
- •3. Aged greater than or equal to 35 years
- •4. Expected to remain in hospital for =48 hours
- •Previous inclusion criteria:
- •1. Pre-existing diagnosis of COPD
- •2. Admission to hospital principally for an exacerbation of COPD
- •3. Aged greater than or equal to 35 years
- •4. Able to enter the study within 48 hours of admission
排除标准
- •1. Prior diagnosis of diabetes mellitus requiring insulin or oral hypoglycaemic therapy
- •2. Hypersensitivity to metformin hydrochloride or to any of the excipients
- •3. Renal impairment
- •4. Severe sepsis
- •5. Metabolic acidosis
- •6. Decompensated type 2 respiratory failure
- •7. Severe congestive cardiac failure
- •8. Acute coronary syndrome
- •9. Hepatic insufficiency
- •10. Excessive alcohol consumption
- •11. Malnourished or at high risk for malnutrition
- •12. Moribund or not for active treatment
- •13. Admitted to critical care unit
- •14. Unable to give informed consent
- •15. Pregnancy or lactation
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