Investigating the effect of wild pistachio gum in the treatment of fatty liver disease

Phase 3

Conditions: Fatty liver.
Fatty (change of) liver, not elsewhere classified
K76.0

Registration Number: IRCT20231219060466N1

Lead Sponsor: Kermanshah University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 46

Inclusion Criteria

Having fatty liver grade 1 and 2 based on diagnosis by ultrasound
Age 18-60 years
Body mass index in the range of 25-35 kg/m2

Exclusion Criteria

The presence of secondary causes of hepatic steatosis (such as hepatitis B and C virus, autoimmune hepatitis, hemochromatosis, celiac disease, pituitary hypofunction, hypothyroidism, Wilson's disease, abetalipoproteinemia or corticosteroid drugs)
Suffering from diseases such as Autoimmune, digestive, liver diseases (fibrosis, cirrhosis, (HCC, kidney, thyroid and cardiovascular diseases), severe respiratory disease (asthma and chronic bronchitis)
Pregnancy
Breastfeeding
Alcohol consumption, consumption of plant sterols, psyllium and oil Fish, consumption of any kind of vitamins and minerals, nutritional supplements
The existence of allergy to all kinds of Pistachio plant species

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Oxidative stress indicators (MDA, TAC, TOS). Timepoint: Before and after study. Method of measurement: Calorimetric method.;Gene expression of antioxidant enzymes (NQO1, HMOX-1, GCLC). Timepoint: Before and after study. Method of measurement: Real- Time PCR.;Nrf-2 gene expression. Timepoint: Before and after study. Method of measurement: Real- Time PCR.;Serum levels of inflammatory and anti-inflammatory factors (IL-10, IL-6). Timepoint: Before and after study. Method of measurement: ELIZA method.

Secondary Outcome Measures

Name	Time	Method
Fasting insulin. Timepoint: Before and after study. Method of measurement: Calorimetric method.;Fasting blood sugar. Timepoint: Before and after study. Method of measurement: Calorimetric method.;Insulin resistance index (HOMA-IR). Timepoint: Before and after study. Method of measurement: Formula.;Insulin sensitivity index (QUICKI). Timepoint: Before and after study. Method of measurement: Formula.;Function of pancreatic beta cells (HOMA-ß). Timepoint: Before and after study. Method of measurement: Formula.;Liver enzymes (AST, ALT). Timepoint: Before and after study. Method of measurement: Calorimetric method.;Lipid profile (TC, HDL-C, TG, LDL-c). Timepoint: Before and after study. Method of measurement: Enzymatic method.;The degree of hepatic steatosis. Timepoint: Before and after study. Method of measurement: sonography.