Desflurane vs. Sevoflurane in Endovascular Aortic Repair

Phase 4

Completed

• Conditions: Renal Failure
• Interventions: Drug: Sevoflurane; Drug: Desflurane

• Registration Number: NCT03917186
• Lead Sponsor: Begoña Quintana Villamandos

Brief Summary

Randomized Clinical Trial following the evaluation of the impact on renal function in patients undergoing endovascular aortic aneurysm repair with two anesthetics protocols (Desflurane versus Sevoflurane) on the first 24 hours after surgery.

Detailed Description

Randomized Clinical Trial to evaluate the impact on renal function in patients undergoing endovascular aortic aneurysm repair with two anesthetics protocols (Desflurane versus Sevoflurane) on the first 24 hours after surgery.

Secondary Endpoint: Among secondary endpoints we will evaluate clinical variables such emergence and recovery characteristics (time to extubation and time to emergence-open eyes and response to verbal command), the need for postoperative mechanical ventilation, the post-anesthesia recovery score and ICU length of stay.

Study Timeline

• Study Start: 2017-09-20
• Study First Submitted: 2017-09-25
• Study First Submitted QC: 2019-04-12
• Study First Posted: 2019-04-16
• Primary Completion: 2020-12-31
• Study Completion: 2021-03-16
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-20
• Last Update Posted: 2023-11-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• older than 18 years undergoing elective endovascular aortic repair
• who have signed informed consent

Exclusion Criteria

• urgent surgery
• with known hypersensitivity to Desflurane or Sevoflurane.
• Renal failure in hemodialysis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group sevoflurane	Sevoflurane	Administration under labelling conditions
Group desflurane	Desflurane	Administration under labelling conditions

Primary Outcome Measures

Name	Time	Method
Change in Biochemical parameters	will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups	osmolarity(mOsm/Kg) in urine

Secondary Outcome Measures

Name	Time	Method
Need for postoperative mechanical ventilation	24 hours	hours of mechanical ventilation in ICU
ICU length of stay	up to 24 hours	hours in ICU
anesthetic recovery	These variable will be recorded immediately after surgery (from anesthetics discontinuation). The postanesthesia recovery score before will be recorded at baseline and after surgery. timeframe 1 hour(stimated)	The post-anesthesia recovery score ( Modified Aldrete score) (0-1-2 from worse to better)

Trial Locations

Locations (1)

Hospital general universitario Gregorio Marañón; 🇪🇸 Madrid, Spain