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Recruiting
- Conditions
- Metbolic syndrome patients with glucsoe intoleranceHigh-glucose induced inflammation and endothelial dysfunctionPatienten met het metabool syndroom en glucose intolerantieHoog-glucose geinduceerde inflammatie en endotheel dysfunctie
- Registration Number
- NL-OMON27220
- Lead Sponsor
- Maastricht University, Research institute Nutrim
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
1. Males and females, aged between 40 and 70 years;
2. Fasting blood glucose levels between 5.5 and 7.8 mmol/l, or diagnosed as having mild type 2 diabetes, but not use insulin;
Exclusion Criteria
1. Have or have had hypersensitivity or allergic reactions for strawberries;
2. Use of insulin;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Glucose-induced production of E-selectin (ELISA), Il-6 (Q-PCR) and IL-1beta(Q-PCR) 2 h after consumption of 75 gram glucose. Timepoint: day 16 vs. day 1;<br /><br>2. Markers of oxidative stress, i.e. 8-oxodG in PBMC's, malondialdehyde and isoprostanes in blood and urine. Timepoint: day 16 vs. day 1.
- Secondary Outcome Measures
Name Time Method Glucose tolerance and insulin sensitivity (HOMA-index). Timepoint: day 16 vs. day 1.