Role of CD4+CD25+FoxP3+ Regulatory T Cells in Pathogenesis of Primary IgA Nephropathy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- proportion averages of cells CD4+CD25+CD127 low T in peripheral blood
研究概览
简要总结
Along structural IgA abnormalities, hyperproduction of IgA is thought to play a role in the pathogenesis of primary IgA nephropathy. CD4+CD25+Fox3P regulatory T cells are instrumental in suppressing adaptative immune responses, including B cells production of immunoglobulins. We, the researchers at Centre Hospitalier Universitaire de Saine Etienne, will test the hypothesis that IgA production in patients with IgA nephropathy is dysregulated because of a quantitative and/or qualitative defect of CD4+CD25+FoxP3+ regulatory T cells.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with pathogenesis of Berger's disease confirmed by renal biopsy
- •Glomerular filtration > 60 ml/min/1,73m2
- •Written informed consent
- •Patient affiliated to social insurance
排除标准
- •Immunosuppressor treatment within 6 months before the study inclusion
- •Clinical infection within 2 months before the study inclusion
- •C-reactive protein (CRP) > 10 mgL-1
研究组 & 干预措施
1
Patient affected by Berger's disease confirmed by renal biopsy with increased rate of Ig A
干预措施: gene transcription and cytometry (Procedure)
2
Patient affected by Berger's disease with normal rate of Ig A
干预措施: gene transcription and cytometry (Procedure)
3
Healthy volunteers
干预措施: gene transcription and cytometry (Procedure)
结局指标
主要结局
proportion averages of cells CD4+CD25+CD127 low T in peripheral blood
时间窗: inclusion
次要结局
- average relative expression of genes FoxP3, CTLA4, GITR, IL10, TGF-B, OX40, TIM-1, and TIM-3(inclusion)