The effect of Naltrexone, an Opiate Receptor Antagonist, on capsaicin dose-response in male Healthy volunteers (NORAH)

Not Applicable

Completed

• Conditions: Chronic cough; Respiratory; Cough

• Registration Number: ISRCTN35917266
• Lead Sponsor: South Manchester University Hospital (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-09-10
• Last Update Posted: 8 January 2018

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

1. Male
2. Aged 18 - 75 years old
3. Normal lung function
4. No current or past history of chronic cough or chronic respiratory illness
5. No current or past history of chronic pain, irritable bowel syndrome or chronic headaches
6. No current or past history of psychiatric illness
7. No current history of reflux disease or post-nasal drip syndrome

Exclusion Criteria

1. Age >75 years
2. Recent upper respiratory tract infection (<4weeks)
3. Use of ACE inhibitors
4. Use of centrally acting medications that may affect the cough reflex
5. History of drug or alcohol abuse
6. Current smoker or ex-smoker with >10 pack year smoking history
7. A previous or current history of liver disease
8. Dependency on opioids
9. Current use of opiates
10. Known hypersensitivity to naltrexone

Study & Design

• Study Type: Interventional
• Study Design: Not specified