Identifying Changes in Food Behaviors Associated With Beginning GLP-1 Medication

Not yet recruiting

• Conditions: Weight Loss; Food Selection

• Registration Number: NCT06843512
• Lead Sponsor: Penn State University

Brief Summary

In recent years, GLP-1 medications have become a widely employed approach by physicians to address weight concerns in patients and lead to weight loss. Little is known, however, about how these medications may alter an individual's attitude towards food, food reactivity, or the specific types and amounts of foods an individual will choose. The purpose of this study is to observe the changes an individual experiences in their relationship and reaction to food and in their food selection prior to or within the first two weeks of taking GLP-1 medication to after three months on the medication. The researchers of this study believe that an understanding of such changes can inform questions seeking to ensure maintenance of appropriate nutrient balance within individuals on weight loss medications.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2025-02-20
• Study First Submitted QC: 2025-02-20
• Study First Posted: 2025-02-25
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-15
• Last Update Posted: 2025-05-20
• Study Start: 2025-06
• Primary Completion: 2025-09
• Study Completion: 2025-09

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• Adults (18+) with overweight or obesity (BMI >25 kg/m2)
• Not currently taking an incretin-based medication at baseline
• Recently (within two weeks) prescribed a GLP-1, can be included if they have a obesity-related co-occurring condition (diabetes, hypertension, cardiovascular disease, dyslipidemia)
• Have had no prior diagnosis of cognitive or physical disability, dyslexia, or epilepsy.
• Fluent in English

Exclusion Criteria

• Adults (18+) without overweight or obesity
• <18 years of age at time of testing
• Adults not taking a GLP-1 Medication
• Adults taking a compound GLP-1
• Adults on GLP-1 medication for longer than 2 weeks at baseline
• Have had a prior diagnosis of cognitive or physical disability, dyslexia, or epilepsy.
• Not fluent in English

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change from Baseline in Total Weight of Food Selected in the VR Buffet at 3 Months	Baseline and 3 months
Change from Baseline in Total Calories of Food Selected in the VR Buffet at 3 Months	Baseline and 3 months
Change from Baseline in Energy Density of Food Selected in the VR Buffet at 3 Months	Baseline and 3 months
Change from Baseline in Variety of Food Selected in the VR Buffet at 3 Months	Baseline and 3 months

Secondary Outcome Measures

Name	Time	Method
Change in Baseline Weight Watchers Food Noise Score at 3 Months	Baseline and 3 months	Based on participant's answers to the WW Food Noise questionnaire; Scale of 1-5, 1 being strongly disagree and 5 being strongly agree; Higher scores mean more food noise
Change in Baseline 9-question External Food Cue Responsiveness Questionnaire Score at 3 Months	Baseline and 3 months	Answers are on a 1-4 scale with 1 being "Rarely" and 4 being "A lot"; higher scores suggest more external food cue reactivity
Change in Baseline Adult Eating Behavior Score at 3 Months	Baseline and 3 months	Answers on a 1-5 scale with 1 being "Strongly disagree" and 5 being "Strongly agree"; 8 subscales, high scores indicate greater expression of subscale measure
Change in Baseline Three-Factor Eating Questionnaire Score at 3 Months	Baseline and 3 months	Rated on a scale of 1-4 with 1 being "Definitely false" and 4 being "Definitely true"; 3 subscales, higher scales on each means greater expression of that behavior
Change in Baseline General Food Craving-Trait Scale Score at 3 Months	Baseline and 3 months	Rated on a 0-5 scale with 0 being "Never/not applicable" and 5 being "Always"; higher scores mean more food dependent
Change in Baseline Buffet Food Liking Scores at 3 Months	Baseline and 3 months	Rated on a 0-100 scale with 0 being "Dislike extremely" and 100 being "Like extremely"; high scores mean greater liking of the food

Trial Locations

Locations (1)

Health, Ingestive Behavior, and Technology Laboratory of Pennsylvania State University; 🇺🇸 State College, Pennsylvania, United States