Developing the strategies of antimicrobial treatment for blood stream infections due to carbapenem resistant klebsiella pneumoniae
Not Applicable
- Conditions
- Health Condition 1: A415- Sepsis due to other Gram-negativeorganisms
- Registration Number
- CTRI/2024/03/063630
- Lead Sponsor
- Indian Council of Medical Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
patients diagnosed with blood stream infections due to carbapenem resistant klebsiella penumoniae anytime during their hospital stay.
Exclusion Criteria
patients received from outside hospital who had a positive culture for bacteremia after 48 hours, patients with polymicrobial bacteremia, patients with cystic fibrosis, patients who do not have a carbapenem susceptibility test or noninterpretable susceptibility test
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The integrated stewardship approach based on evidence-based recommendation will help to develop a standard treatment guideline for difficult to treat CR-Kp infections.Timepoint: After obtaining culture positive sample for Cr-Kp
- Secondary Outcome Measures
Name Time Method Cost-effectiveness analysis of incorporating PCR techniques in CR-Kp will help in better management of patients in low-middle socioeconomic countries like India.Timepoint: Throughout the hospital stay of the patients based on clinical outcomes;Optimization of appropriate antibiotic regimen based on the genotype of CR-Kp will help in individualized antimicrobial therapy, providing better outcomes of the patient & prevent treatment failure or antimicrobial resistance.Timepoint: After obtaining a positive blood culture for Cr-Kp