Non-invasive Evaluation of Volume Status Using Exhaled Carbon Dioxide and Pulse Contour Analysis
- Conditions
- Changes in Cardiac Output
- Interventions
- Other: Ventricular pacing and passive leg raise
- Registration Number
- NCT02070861
- Lead Sponsor
- Oslo University Hospital
- Brief Summary
The investigators hypothesize that changes in blood circulation can be reflected by exhaled CO2 provided CO2-production in the tissues and ventilation from the lungs are stable. The investigators want to explore changes in cardiac output (the amount of blood being pumped out of the heart each minute) in patients using different devices: an esophagus ultrasound device measuring cardiac output, a finger cuff measuring blood pressure and cardiac output, and exhaled carbondioxide in the patients' breath measured by the ventilator.
The investigators investigate patients after bypass surgery or heart valve replacement, and induce changes in cardiac output with passive leg raise or ventricular pacing.
- Detailed Description
Measurements with the finger cuff (pulse contour analyses) were aborted due to technical difficulties.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 33
- Persons 18 years or older scheduled to undergo arteriocoranary bypass surgery or aortic valve replacement.
- Esophageal pathology, EF <40%
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Comparing cardiac output changes Ventricular pacing and passive leg raise Explore the relationship between changes in cardiac output measured with eosophagal Doppler, the volume-clamp-method and exhaled CO2 during ventricular pacing and passive leg raise. Measurements with the volume-clamp-method were aborted due to technological difficulties.
- Primary Outcome Measures
Name Time Method Changes in cardiac output 5 Minutes
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Oslo University Hospital, Ullevål
🇳🇴Oslo, Norway