Estimation of Pulmonary Capillary Blood Volume in Pre- and Postcapillary Pulmonary Hypertension

Completed

• Conditions: Hypertension Pulmonary
• Interventions: Other: assessment of DLNO and DLCO

• Registration Number: NCT02789449
• Lead Sponsor: Medical University of Graz

Brief Summary

The aim of the study is to investigate the role of the non-invasive assessment of nitric oxyde (NO) diffusion capacity (DLNO) in the differential diagnosis of different forms of pulmonary hypertension (PH). DLNO alone and in combination with the measurement of carbon monoxide (CO) diffusion capacity (DLCO) may help to differentiate between pre- and postcapillary forms of pulmonary hypertension. This hypothesis is based on the fact that NO has a much higher affinity to hemoglobin as compared to CO and may therefore its decrease may more specifically identify the limiting factors between the alveolar space and the lung capillaries including left heart failure (cardiac edema).

As there are no available published data yet to answer this question investigators aim to perform a small pilot study. The results of this study may allow the planning of a prospective study.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-11
• Study First Submitted: 2016-04-22
• Study First Submitted QC: 2016-05-30
• Study First Posted: 2016-06-03
• Primary Completion: 2018-12-31
• Study Completion: 2018-12-31
• Status Verified: 2020-03
• Last Update Submitted: 2020-03-17
• Last Update Posted: 2020-03-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 17

Inclusion Criteria

• patients undergoing right heart catheterization
• patients with clear precapillary PH (PAWP<12mmHg) or clear postcapillary PH (PAWP>18mmHg)
• signed informed consent

Exclusion Criteria

• patients unable to perform the DLCO test

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
postcapillary	assessment of DLNO and DLCO	patients with PH and PAWP\>18mmHg
precapillary	assessment of DLNO and DLCO	patients with PH and PAWP\<12mmHg

Primary Outcome Measures

Name	Time	Method
Difference in DLNO (in mmol/min/kPa) between the two predefined groups (patients with clear precapillary PH (PAWP<12mmHg) vs. clear postcapillary PH (PAWP>18mmHg))	one hour

Trial Locations

Locations (1)

Medical University Graz, Division of Pulmonology; 🇦🇹 Graz, Steiermark, Austria