Associations of Exposure to Bisphenol A With Blood Pressure and Epigenetic Change

Not Applicable

Completed

• Conditions: Hypertension
• Interventions: Other: Can 1; Other: Can 2; Other: Glass

• Registration Number: NCT02096991
• Lead Sponsor: Seoul National University Hospital

Brief Summary

* Bisphenol A(BPA) is an endocrine disrupting chemical, which mimics the action of estrogen.

* Previous studies reported that BPA exposure is associated with increased risk of cardiovascular diseases.

* Exposure to BPA occur mainly through oral route, and epoxy coating of canned food is one of the well established source.

* The investigators hypothesis is that increased BPA exposure from canned beverage would disrupt normal physiology in a short term.

* In the present trial the investigators are to investigate whether increased BPA exposure by consuming canned beverage actually affect cardiovascular indices and epigenetic feature.

* For this aim, the investigators will conduct a cross-over trial.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-02
• Study First Submitted: 2014-02-02
• Status Verified: 2014-03
• Primary Completion: 2014-03
• Study Completion: 2014-03
• Study First Submitted QC: 2014-03-23
• Last Update Submitted: 2014-03-23
• Study First Posted: 2014-03-26
• Last Update Posted: 2014-03-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Reside in Seoul
• Who provided Informed consent

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Exclusion Criteria

• Who has cancer
• Who has disease or disorder of liver, nervous system, endocrine system, cardiovascular system
• Who does not provieded informed consent

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Glass	Can 2	consume beverage in glass first and cross over to other interventions
Glass	Can 1	consume beverage in glass first and cross over to other interventions
Glass	Glass	consume beverage in glass first and cross over to other interventions
Can 1	Can 1	consume one canned beverage and a glass bottled beverage first and cross over to other interventions
Can 1	Can 2	consume one canned beverage and a glass bottled beverage first and cross over to other interventions
Can 1	Glass	consume one canned beverage and a glass bottled beverage first and cross over to other interventions
Can 2	Can 1	Consume two canned beverage first and cross over to other interventions
Can 2	Can 2	Consume two canned beverage first and cross over to other interventions
Can 2	Glass	Consume two canned beverage first and cross over to other interventions

Primary Outcome Measures

Name	Time	Method
Blood Pressure	2 hours after consuming beverage

Secondary Outcome Measures

Name	Time	Method
Heart Rate Variablility	2 hours after consuming the beverage
Percent DNA methylation	2 hours after consuming the beverage

Trial Locations

Locations (1)

Department of Preventive Medicine, College of Medicine, Seoul National University; 🇰🇷 Seoul, Korea, Republic of