Associations of Exposure to Bisphenol A With Blood Pressure and Epigenetic Change
- Conditions
- Hypertension
- Registration Number
- NCT02096991
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
* Bisphenol A(BPA) is an endocrine disrupting chemical, which mimics the action of estrogen.
* Previous studies reported that BPA exposure is associated with increased risk of cardiovascular diseases.
* Exposure to BPA occur mainly through oral route, and epoxy coating of canned food is one of the well established source.
* The investigators hypothesis is that increased BPA exposure from canned beverage would disrupt normal physiology in a short term.
* In the present trial the investigators are to investigate whether increased BPA exposure by consuming canned beverage actually affect cardiovascular indices and epigenetic feature.
* For this aim, the investigators will conduct a cross-over trial.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- Reside in Seoul
- Who provided Informed consent
- Who has cancer
- Who has disease or disorder of liver, nervous system, endocrine system, cardiovascular system
- Who does not provieded informed consent
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Blood Pressure 2 hours after consuming beverage
- Secondary Outcome Measures
Name Time Method Heart Rate Variablility 2 hours after consuming the beverage Percent DNA methylation 2 hours after consuming the beverage
Trial Locations
- Locations (1)
Department of Preventive Medicine, College of Medicine, Seoul National University
🇰🇷Seoul, Korea, Republic of
Department of Preventive Medicine, College of Medicine, Seoul National University🇰🇷Seoul, Korea, Republic of