Analysis of BPA Concentration in Serum in Women of Reproductive Age With Autoimmune Thyroid Disease

Completed

• Conditions: Graves Disease; Hypothyroidism; Hyperthyroidism; Hashimoto Disease

• Registration Number: NCT04682340
• Lead Sponsor: Jagiellonian University

Brief Summary

The aim of the study is to assess the relationship between the concentration of bisphenol A in serum and selected parameters of thyroid function in women of reproductive age with thyroid dysfunction - Hashimoto's disease and Graves' disease.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-12-13
• Study First Submitted QC: 2020-12-18
• Study Start: 2020-12-22
• Study First Posted: 2020-12-23
• Primary Completion: 2021-10-30
• Status Verified: 2022-01
• Study Completion: 2022-01-19
• Last Update Submitted: 2022-01-19
• Last Update Posted: 2022-01-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 80

Inclusion Criteria

• Graves' disease or Hashimoto's disease (positive thyroid autoantibody)
• Control group: thyroid autoantibody negative, normal thyroid function
• Women aged 18 to 45 in both the control group and experimental group

Exclusion Criteria

• Pregnancy and lactating women
• Previous or planned treatment with 131I or thyroidectomy
• The use of drugs affecting the thyroid function (lithium, amiodarone, interferon a, sodium nitroprusside, sunitinib, sorafenib, iodine contrast, antibiotics / antifungals / antivirals (for at least 4 weeks prior to recruitment to the study), which do not result from the treatment of thyroid disease (levothyroxine, thyreostatic drugs, glucocorticoids)
• Active malignancy
• Other autoimmune diseases
• Other endocrine diseases
• Patients with severe liver, kidney or heart failure

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of serum BPA levels between the group with AITD and control group	Dec 2020 - April 2021

Secondary Outcome Measures

Name	Time	Method
The association between serum BPA levels and serum thyroid hormone levels in the AITD group	Dec 2020 - April 2021	To determine the association between serum BPA concentrations and serum thyroid hormone levels in adult women

Trial Locations

Locations (1)

Jagiellonian University Medical College; 🇵🇱 Kraków, Malopolska, Poland