The effects of the synbiotic Ecologic 825/scFOS on intestinal barrier function and immune modulatio
Completed
- Conditions
- gastrointestinal symptoms10017966
- Registration Number
- NL-OMON38875
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
no gastrointestinal complaints
age between 18 and 65 yrs
BMI between 20 and 30 kg/m^2
Exclusion Criteria
Use of medication within 14 days prior to testing
Administration of probiotics, investigational drugs, or participation in a scientific intervention study in the 180 days prior to testing
Use of antibiotics in the 90 days prior to testing
women; pregnancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>• Sugar recovery in urine, as indicator of intestinal permeability </p><br>
- Secondary Outcome Measures
Name Time Method <p>- Measurements in blood at baseline and after the supplementation period<br /><br>• Biomarkers of immune modulation; plasma levels of TNFa, IL-1b, IL-6, IL-8,<br /><br>IL-17, MCP-1 and MIP-1a<br /><br>- Measurements in small intestinal fluid (duodenum/jejunum/ileum) and feces<br /><br>• Relative abundance of CRIB<br /><br>• Microbial diversity and population dynamics<br /><br>• In situ gene expression of the microbiota<br /><br>- Questionnaire at baseline, during and after the supplementation period<br /><br>• The symptom diary </p><br>