The Early Origins of Cardiovascular Disease

• Conditions: Cardiovascular Disease

• Registration Number: NCT00923039
• Lead Sponsor: Danone Institute International

Brief Summary

Small body size at birth, slow weight gain during infancy and increase in body mass index after 2 years are independent risk factors for cardiovascular disease and the metabolic syndrome. There is a large gap in our understanding of how early growth affects the cardiovascular system. Possible mechanisms include alterations in body composition, in cardiac structure, in vascular function, in renal function and epigenetic processes.

The Objective is to determine how size at birth and growth during infancy and childhood affect: body composition, cardiac structure and function, vascular and endothelial function, renal function, metabolic status and transcriptional and epigenetic characteristics.

Detailed Description

Not available

Study Timeline

• Status Verified: 2009-06
• Study Start: 2009-06
• Study First Submitted: 2009-06-17
• Study First Submitted QC: 2009-06-17
• Last Update Submitted: 2009-06-17
• Study First Posted: 2009-06-18
• Last Update Posted: 2009-06-18

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Male and female volunteers students aged between 18-25 years old
• Having growth records

Exclusion Criteria

• If young women subject without contraception,or pregnant

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine how size at birth and growth during infancy and childhood affect: body composition, cardiac structure and function, vascular and endothelial function, renal function, metabolic status and transcriptional and epigenetic characteristics	3 years

Trial Locations

Locations (1)

CIC-UPCET Hopital de la Timone Bat F; 🇫🇷 Marseille, France