Effect of Electroacupuncture in Patients With Sepsis Associated Brain Injury
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- soluble protein-100β,S100β
研究概览
简要总结
To investigate the effect of electroacupuncture on patients with sepsis-associated brain injury.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Sequential
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age is between 20 and 80 years.
- •Patients meeting the diagnosis of sepsis-associated brain injury.
- •Patients who agreed to accept this trial and signed the informed consent form.
排除标准
- •Patients with a history of brain injury, stroke, epilepsy, cognitive impairment, or mental illness prior to admission.
- •Patients who were also involved in any other interventional study.
- •Due to hearing or vision loss, or any other situation that may seriously interfere with study data collection.
- •Patients who refused to participate in this study.
- •The pregnancy test was positive or is currently breastfeeding.
- •Any other situation that the investigator believed might be detrimental to participant in the study.
研究组 & 干预措施
electroacupuncture
The investigators choose Zusanli (ST36) and Baihui (DU20) acupoints to investigate the effect of electroacupuncture on patients with sepsis-associated brain injury.
干预措施: electroacupuncture (Other)
shame electroacupuncture
The shame electroacupuncture were performed at a shallow depth and 1 mm lateral to Zusanli (ST36) and Baihui (DU20) acupoints.
干预措施: shame electroacupuncture (Other)
结局指标
主要结局
soluble protein-100β,S100β
时间窗: Change of S100β from Baseline at 7 days
Serum index of sepsis-associated brain injury.
neuron specific enolase,NSE
时间窗: Change of NSE from Baseline at 7 days
Serum index of sepsis-associated brain injury.
sTREM2
时间窗: Change of sTREM2 from Baseline at 7 days
Serum index of sepsis-associated brain injury.
次要结局
- Glasgow Coma Scale，GCS(Change of GCS from Baseline at 7 days)
- Montreal Cognitive Assessment (MoCA) scale(Change of MoCA from Baseline at 7 days)
- Acute Physiology and Chronic Health Evaluation，APACHE II(Change of APACHE II from Baseline at 7 days)
研究者
Jianbo Yu
Director
Tianjin Nankai Hospital