Urogenital Infections in Women of Reproductive Age and the Activity of 4-Thiazolidinone Derivatives Against Pathogens
Phase 1
Active, not recruiting
- Conditions
- Bacterial Vaginosis
- Interventions
- Diagnostic Test: Microbiological identification kits (ANAEROtest, STAPHYtest, ENTEROtest, NEFERMtest)Drug: Antibiotic therapy after the results of antibiotic sensitivity test (Mostly Oxacillin, Benzylpenicillin, Ceftriaxone, Doxycycline, Clindamycin)Combination Product: Suppositoria for vaginal microflora recovery (Giynoflor)Drug: Antifungal therapy (Mostly Fluconazole, Nystatin, Amphotericin B)
- Registration Number
- NCT06616168
- Lead Sponsor
- Danylo Halytsky Lviv National Medical University
- Brief Summary
Research concerning women pathogenic microflora during different conditions
- Detailed Description
Study of microflora of different groups of women of reproductive age, determination of pathogens and their further study, samples of a newly synthesized compound on isolated pathogens
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- Female
- Target Recruitment
- 200
Inclusion Criteria
- urogenital infections, pregnancy
Exclusion Criteria
- healthy microflora
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Women with bacterial vaginosis Microbiological identification kits (ANAEROtest, STAPHYtest, ENTEROtest, NEFERMtest) Women with bacterial vaginosis (symptomatic or asymptomatic) Women with bacterial vaginosis Antibiotic therapy after the results of antibiotic sensitivity test (Mostly Oxacillin, Benzylpenicillin, Ceftriaxone, Doxycycline, Clindamycin) Women with bacterial vaginosis (symptomatic or asymptomatic) Women with bacterial vaginosis Suppositoria for vaginal microflora recovery (Giynoflor) Women with bacterial vaginosis (symptomatic or asymptomatic) Women with bacterial vaginosis Antifungal therapy (Mostly Fluconazole, Nystatin, Amphotericin B) Women with bacterial vaginosis (symptomatic or asymptomatic) Pregnant women Microbiological identification kits (ANAEROtest, STAPHYtest, ENTEROtest, NEFERMtest) Pregnant women with different ifections Pregnant women Antibiotic therapy after the results of antibiotic sensitivity test (Mostly Oxacillin, Benzylpenicillin, Ceftriaxone, Doxycycline, Clindamycin) Pregnant women with different ifections Pregnant women Suppositoria for vaginal microflora recovery (Giynoflor) Pregnant women with different ifections Pregnant women Antifungal therapy (Mostly Fluconazole, Nystatin, Amphotericin B) Pregnant women with different ifections Women with asymptomic infections Microbiological identification kits (ANAEROtest, STAPHYtest, ENTEROtest, NEFERMtest) Women with asymptomic infections of urogenital tract Women with asymptomic infections Antibiotic therapy after the results of antibiotic sensitivity test (Mostly Oxacillin, Benzylpenicillin, Ceftriaxone, Doxycycline, Clindamycin) Women with asymptomic infections of urogenital tract Women with asymptomic infections Suppositoria for vaginal microflora recovery (Giynoflor) Women with asymptomic infections of urogenital tract
- Primary Outcome Measures
Name Time Method Estimation of the immune activity 1 month Detection of quantities of different immune cells: lymphocytes, leukocytes, neutrophils, eosinophils
Quantities of vaginal microflore bacteria 2 months Detection of quantities of vaginal microflore bacteria before and after antibiotic therapy (in TBC)
- Secondary Outcome Measures
Name Time Method Quantities of bacteria in urine 2 months Detection of quantities of bacteria in urine (in TBC)
Trial Locations
- Locations (1)
Danylo Halytsky Lviv National Medical University
🇺🇦Lviv, Ukraine