Exploring the Relationship Between Insulin Resistance and Interferon Resistance: Options to Overcome HCV Non-Response to Pegylated Interferon - The Relationship Between Insulin Resistance and Interferon resistance

Imperial College London0 个研究点目标入组 22 人开始时间: 2010年3月17日最近更新: 2020年10月13日

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•1.Chronic HCV genotype 1 infection
•2.Chronic HCV and compensated liver cirrhosis who failed to respond to previous treatment.
•2.Age >17, <70
•3.Eligible for interferon therapy
•Are the trial subjects under 18?
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years)
•F.1.3.1 Number of subjects for this age range

•1.HIV or HBV co-infection.
•2.Current use antidiabetic medication (eg insulin, metformin or thiazolidinedione).
•3.Significant respiratory, cardiac or renal dysfunction
•4.Body Mass Index > 30 kg/m2
•5. Patients with manifestations of hepatic impairment in form of hepatic decompensation. This include any patient with:
•?Clinically: history of ascites, jaundice, hepatic encephalopathy or bleeding oesophageal varices
•?Laboratory: prolonged prothrombin time, low albumin level (<33 g/l) or high billirubin level.
•?Imaging: evidence of ascites by abdominal ultrasound

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