Exploring the Relationship Between Insulin Resistance and Interferon Resistance: Options to Overcome HCV Non-Response to Pegylated Interferon - The Relationship Between Insulin Resistance and Interferon resistance

Imperial College London0 sites22 target enrollmentMarch 17, 2010

Overview

No summary available.

Registry

who.int

Start Date

March 17, 2010

End Date

December 1, 2009

Last Updated

5 years ago

Study Type

Interventional clinical trial of medicinal product

Sex

All

Sponsor

•1\.Chronic HCV genotype 1 infection
•2\.Chronic HCV and compensated liver cirrhosis who failed to respond to previous treatment.
•2\.Age \>17, \<70
•3\.Eligible for interferon therapy
•Are the trial subjects under 18?
•Number of subjects for this age range:
•F.1\.2 Adults (18\-64 years) yes
•F.1\.2\.1 Number of subjects for this age range
•F.1\.3 Elderly (\>\=65 years)
•F.1\.3\.1 Number of subjects for this age range

•1\.HIV or HBV co\-infection.
•2\.Current use antidiabetic medication (eg insulin, metformin or thiazolidinedione).
•3\.Significant respiratory, cardiac or renal dysfunction
•4\.Body Mass Index \> 30 kg/m2
•5\. Patients with manifestations of hepatic impairment in form of hepatic decompensation. This include any patient with:
•?Clinically: history of ascites, jaundice, hepatic encephalopathy or bleeding oesophageal varices
•?Laboratory: prolonged prothrombin time, low albumin level (\<33 g/l) or high billirubin level.
•?Imaging: evidence of ascites by abdominal ultrasound