EUCTR2013-003800-38-DK进行中（未招募）1 期
The effects of tolvaptan on renal handling of water and sodium, vasoactive hormones and circulatory system, during basal conditions and during inhibition of the nitric oxide system in healthy subjects. A dose-response study. - DOVA
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 入组人数
- 22
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •1) Caucasian men and women
- •2) age 18-40 years
- •3)BMI between 18.5 and 30 kg/m2.
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 22
- •F.1.3 Elderly (>=65 years) no
- •F.1.3.1 Number of subjects for this age range
排除标准
- •1) Arterial hypertension, defined as consultation blood pressure above 140 mmHg systolic and / or 90 mmHg diastolic. 2) Medically important or clinical signs of diseases of the heart, lungs, liver, endocrine organs and brain or neoplastic disease, 3) alcohol or drug abuse, 4) medical treatment except oral contraceptives, 5) smoking, 6) pregnancy or breastfeeding, 7) clinically important abnormalities in blood or urine sample at the inclusion 8) clinically important changes in the electrocardiogram, 9) blood donation for the past month prior to the examination days, and 10) allergy to tolvaptan.
研究者
相似试验
已完成
不适用
The effect of tolvaptan on renal function during intensive treatment in patients with congestive heart failurecongestive heart failureJPRN-UMIN000014134ishiarai Heart Center Hospital80
招募中
不适用
Study of the renal protective effect of tolvaptan as a replacement of loop diuretics for the treatment of ascites in cirrhotic patients with renal dysfunctioliver cirrhosisJPRN-UMIN000044693Tohoku Medical and Pharmaceutical University15
进行中（未招募）
1 期
Effects of the diuretic tolvaptan on nitric oxide systemSIADH (Syndrome of inappropriate ADH production)OverhydrationHyponatrimiaMedDRA version: 14.1Level: LLTClassification code 10021038Term: HyponatremiaSystem Organ Class: 10027433 - Metabolism and nutrition disordersMedDRA version: 14.1Level: LLTClassification code 10040626Term: SIADHSystem Organ Class: 10014698 - Endocrine disordersEUCTR2012-001169-33-DKDepartment of Medical Research20
已完成
不适用
Renal protective effect of Samsca in patients with new-onset acute heart failureAcute heart failureJPRN-UMIN000036417Kansai Medical University Medical Center122
已完成
2 期
Effect of the Aquaretic Tolvaptan on Nitric Oxide System. A Dose-response Study (DOVA)NephropathyNCT02078973Regional Hospital Holstebro15