The study to prevent and reduce postoperative nausea and vomiting due to continuous epidural administratio
Not Applicable
- Conditions
- patients scheduled for abdominal gynecological surgery under general-epidural anesthesia
- Registration Number
- JPRN-UMIN000017055
- Lead Sponsor
- Saiseikai Narashino Hospital
- Brief Summary
The incidences rate of PONV were 27.9% (doropeidol group) and 58.1% (epinephrine group), respectively (P=0.0046, odds ratio 0.279, NNT 3.13). The use frequency of the antiemetics were 18.6% and 41.9%, respectively (P=0.0189, odds ratio 0.317, NNT 4.29). There was one patient who had to cancel continuous epidural administration for vomiting in epinephrine group, but no patient in doropeidol group.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Female
- Target Recruitment
- 84
Inclusion Criteria
Not provided
Exclusion Criteria
age<18, >=80, ASA-PS<=3, BMI<=35, QT prolongation, Parkinson's disease, psychiatric history, drug abuser, steroid administration
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method the incidences of PONV, the use frequency of the antiemetics
- Secondary Outcome Measures
Name Time Method the incidences of cancelling continuous epidural administration for vomiting, the use frequency of the adjuvant analgesic, the incidences of pruritus, the incidences of reduction in blood pressure