Investigating Magnetic Seizure Therapy in Major Depressive Disorder.

Completed

• Conditions: Treatment Resistant Major Depression; Mental Health - Depression

• Registration Number: ACTRN12611000054910
• Lead Sponsor: Professor Paul Fitzgerald

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-01-17
• Study Completion: 2016-06-01
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Age 18-75 and a DSM-IV diagnosis of a major depressive episode (uni or bipolar depression) (diagnosis made using the standard structured clinical interview for the DSM-IV (SCID I) instrument).

Patients with psychotic symptoms as part of their mood episode will not be excluded if able to give informed consent.

Are referred for or are otherwise suitable for a course of ECT as determined by their treating psychiatrist

Hamilton Depression Rating Scale (17 item version) score of > 18 (moderate – severe depression): note – some authors have defined moderate depression on the 17 item HAMD as >14. We have selected a higher cut off to ensure all patients clearly have depression of substantial clinical severity. It is likely that most patients will have scores in the severe or extremely severe ranges.

Score greater than 23 on the Mini Mental State Examination

Have treatment resistant depression at Stage II of the Thase and Rush classification. This requires failure to respond to adequate courses of several courses of antidepressants.

Demonstrated capacity to give informed consent

Exclusion Criteria

Patients who are too unwell to undergo general anesthetic.

Patients with metallic implants in the head, cardiac pacemakers, cochlear implants or other implanted electronic devices

Treatment with ECT in the last three months

Presence of another DSM-IV Axis I psychiatric disorder (on SCID I) other than bipolar disorder

Presence of substance abuse or dependence during the last six months (on SCID I)

Current pregnancy

Past history of stroke, neurodegenerative disorder or other major neurological illness

Study & Design

• Study Type: Interventional
• Study Design: Not specified