Pre-eclampsia and Biochemical Markers
Completed
- Conditions
- Detection of Preeclampsia Complications
- Registration Number
- NCT02665897
- Lead Sponsor
- Assiut University
- Brief Summary
In view of both endothelial injury in pre-eclampsia, high blood pressure and kidney impairment characteristics, a recent study demonstrated that the serum levels of NGAL increased at the end of the second trimester in women who subsequently developed pre-eclampsia compared to the control group.
This correlates well with the endothelial damage that occurs during pre-eclampsia and thus NGAL can be considered as a promising marker in predicting both early and late onset pre-eclampsia. It may be required to combine one or more biomarker with NGAL to increase the precision, and sensitivity for detection of risk and reliability of using biomarkers for pre-eclampsia.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 90
Inclusion Criteria
- Age 20-40 years.
- Gestational age >20 weeks.
Exclusion Criteria
- Patients with preexisting renal disease,hypertension, diabetes mellitus, gestational hypertension.
- Patients Refuse to participate in the study
- Patients already have complicated preeclampsia.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The level of circulating NGAL 24 hours
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Ahmed Abbas
🇪🇬Assiut, Cairo, Egypt