Prospective Study : Association Between Pococyturia and Pre-eclampsia Severity
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pre-Eclampsia
- Sponsor
- Hospices Civils de Lyon
- Enrollment
- 14
- Locations
- 2
- Primary Endpoint
- Severity of pre-eclampsia
- Status
- Completed
- Last Updated
- 9 months ago
Overview
Brief Summary
Pre-eclampsia is an hypertensive disorder appearing during pregnancy, inducing serious maternal, fetal and neonatal mortality and morbidity. Twenty four hours proteinuria is a key element to define pre-eclampsia severity but is delaying the result by 24 hours and constraining for the patient. A simple and rapid indicator for severe preeclampsia would help clinicians to make appropriate decision in patient management. We hypothesized that urinary podocyturia is correlated to preeclampsia severity. This is a prospective, non-interventional, monocentric study.
Investigators
Eligibility Criteria
Inclusion Criteria
- •women aged 18 years or more
- •single pregnancy
- •admission for pre-eclampsia
- •patient receiving information and non-opposition to participate
Exclusion Criteria
- •multiple pregnancy
- •in utero fetal demise excepted if associated with pre-eclampsia
- •antecedent of nephropathy
- •fetal malformation, chromosomal anomalies
- •inability to understand information provided
- •prisoner or under administrative supervision
Outcomes
Primary Outcomes
Severity of pre-eclampsia
Time Frame: at childbirth (maximum 10 months)
Severe preeclampsia is defined by preeclampsia with at least one of the following criteria : * severe hypertension (PAS ≥ 160 mmHg et/ou PAD ≥ 110 mmHg) * Renal impairment with: oliguria \<500 ml / 24h or creatinine\> 135 μmol / L or proteinuria\> 5 g/d * acute lung edema or persistent epigastric bar or HELLP syndrome * eclampsia or rebellious neurological disorders (visual disturbances, polykinetic ROT, headache), * thrombocytopenia \<100 G / L * Retro Placental Hematoma (HRP) or fetal repercussion.