Japan-multimodal intervention Trial for prevention of dementia (J-MINT)
Not Applicable
- Conditions
- Older adults with cognitive impairment.
- Registration Number
- JPRN-UMIN000038671
- Lead Sponsor
- ational Center for Geriatrics and Gerontology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 531
Inclusion Criteria
Not provided
Exclusion Criteria
Subjects who 1) are needed to restrict any physical exercise and/or diet due to functional decline, including presence of bone or joint disease, renal faiure, ischemic heart disease, and cardiopulmonary disorders. 2) are diagnosed with dementia. 3) have a MMSE score of less than 24. 4) are unable to speak in Japanese. 5) are unable to perform cognitive tests. 6) have a care-needs certification in the long-term care insurance system. 7) are deemed ineligible for enrollment by the responsible researcher or co-researcher at each institution.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in a composite score of cognitive function from baseline to a 18-month follow-up.
- Secondary Outcome Measures
Name Time Method 1) Changes in a composite score of cognitive tests from baseline to a 6/12-month follow-up. 2) Changes in scores of each cognitive test from baseline to a 6/12/18-month follow-up. 3) Changes in laboratory and urinary markers from baseline to a 6/18-month follow-up. 4) Changes in ADL scores from baseline to a 6/18-month follow-up. 5) Changes in the status of frailty from baseline to a 6/18-month follow-up. 6) Changes in brain images assessed using MRI or CT from baseline to a 18-month follow-up. 7) Changes in the number of medications. 8) Changes in each result of a comprehensive geriatric assement from baseline to a 6/18-month follow-up. 9) Incident dementia.