Phenylephrine Versus Norepinephrine in Septic Shock

Phase 2

Completed

• Conditions: Septic Shock

• Registration Number: NCT00481442
• Lead Sponsor: University of Roma La Sapienza

Brief Summary

Clinical studies evaluating the clinical use of phenylephrine in septic shock are lacking. The present study was designed to compare the effects of norepinephrine and phenylephrine on systemic and regional hemodynamics in patients with catecholamine-dependent septic shock.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-01
• Status Verified: 2007-03
• Study Completion: 2007-03
• Study First Submitted: 2007-05-30
• Study First Submitted QC: 2007-05-30
• Last Update Submitted: 2007-05-30
• Study First Posted: 2007-06-01
• Last Update Posted: 2007-06-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• Clical diagnosis of Septic Shock
• norepinephrine to maintain mean arterial pressure between 65 and 75 mmHg despite adequate volume resuscitation (pulmonary artery occlusion pressure = 12-18 mmHg and central venous pressure = 8-12 mmHg).

Exclusion Criteria

• Age < 18 years
• Pregnancy
• Present or suspected acute coronary artery disease
• Present or suspected acute mesenteric ischemia.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Systemic and regional hemodynamics	24 hours

Secondary Outcome Measures

Name	Time	Method
Organ functions, adverse effects	24 hours

Trial Locations

Locations (1)

Department of Anesthesiology and Intensive care of the University of Rome "La Sapienza"; 🇮🇹 Rome, Italy