Evaluation of serum cystatin C for early diagnosis of acute kidney injury in post exploratory laparotomy patients in intensive care unit
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Evaluation of serum cystatin C for the early diagnosis of AKI in the postoperative exploratory laparotomy patients who will be admitted in the intensive care unit
研究概览
简要总结
Acute kidney injury is commonly seen in the perioperative period and in the ICU and is associated with a prolonged hospital stay and high morbidity and mortality. Upto 30% of all patients admitted in ICU suffer
from acute kidney injury. About 50-90% mortality rate is seen in ICU patients who at the end require renal transplantation. Hence, the need for early diagnosis of acute kidney injury is required for the early intervention with
prompt implementation of therapeutic measures to save lives. Criteria for early diagnosis of acute kidney injury are available including : RIFLE criteria (Risk, Injury ,Failure, Loss and End stage kidney), AKIN (Acute
kidney injury network), KDIGO( Kidney Disease Improving Global Outcomes). All these are based on serial measurement of serum creatinine and urine output. Serum creatinine is the most common and dominant
marker of Glomerular filtration rate used to make diagnosis and to categorize acute kidney injury in the ICU setting. Serum cystatin C is also an alternative endogenous marker of glomerular filtration rate. It is produced by all
nucleated cells at a constant rate, it’s serum level is only determined by glomerular filtration rate. An ideal marker of acute kidney injury is the one which allows for the early detection with high diagnostic sensitivity and
specificity. The present study will be conducted in the Department of Anaesthesia and Intensive care, Government Medical College and Hospital, Chandigarh. 70 postoperative exploratory laparotomy patients
admitted to ICU, will be enrolled in the study based on inclusion / exclusion criteria. 5 ml blood sample will be taken from the patients: on the Day 0 i.e. in first 24 hours of admission to ICU(baseline), 48hours, 72
hours and on day 7 of admission to ICU. Acute kidney injury will be defined according to KDIGO criteria. The immunoturbidimetric method on automated random assess chemistry analyser will be used for the
determination of serum cystatin C level. Serum samples for serum cystatin C will be collected and frozen at -80 degree centigrade. From this study we hypothesize that for the early diagnosis of acute kidney injury in
postoperative laparotomy patient who are admitted in ICU, serum cystatin is a better marker than serum creatinine.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •All patients with age 18 years – 60 years admitted to ICU after post-operative exploratory laparotomy surgery.
排除标准
- •Refusal to consent from patient’s relative Patients recovering from AKI or developing AKI Patients who required renal replacement therapy All patients transferred from another ICU Patients with end stage kidney disease Serum Creatinine beyond range Serum Cystatin C level beyond range Covid 19 and covid 19 suspect patients.
结局指标
主要结局
Evaluation of serum cystatin C for the early diagnosis of AKI in the postoperative exploratory laparotomy patients who will be admitted in the intensive care unit
时间窗: Within 24 hours post admission in ICU(Baseline) | After 48 hours post admission in ICU | After 72 Hours post admission in ICU | Day 7 post admission in ICU
次要结局
- Correlation of serum cystatin C and serum creatinine in early diagnosis of AKI in the postoperative exploratory laparotomy patients who will be admitted in the intensive care unit.(Within 24 hours post admission in ICU(Baseline))