NCT06635408CompletedNot Applicable
Cystatin c as a Predictive Biomarker of Acute Kidney Injury and Neurological Outcomes in Aneurysmal Subarachnoid Haemorrhage Patients
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Alexandria University
- Enrollment
- 52
- Locations
- 1
- Primary Endpoint
- Acute kidney injury
Study Overview
Brief Summary
The goal of this observational study is to assess cystatin c as a predictive biomarker of early acute kidney injury in aneurysmal subarachnoid hemorrhage patients. The main question it aims to answer is:
- Does cystatin c biomarker can predict early acute kidney injury in aneurysmal subarachnoid hemorrhage patients?
Participants will be grouped into Aki and Non-Aki groups based on RIFLE criteria and Cystatin c biomarker will be tested to answer the study question.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Patient admission to hospital within 48 hours of subarachnoid haemorrhage onset.
- •Subarachnoid haemorrhage caused by intracranial aneurysm rupture and is confirmed via computed tomography angiography (CTA).
- •Medical treatment, microsurgical clipping, or interventional endovascular treatment of aneurysm is performed within 48 hours of subarachnoid haemorrhage onset.
Exclusion Criteria
- •Prior onset of subarachnoid haemorrhage or other neurological diseases such as ischemic stroke, hemorrhagic stroke, or severe head trauma.
- •Systemic diseases, such as chronic liver diseases, chronic lung diseases, chronic heart failure, thyroid diseases and cancer.
- •Renal impairment at time of admission (creatinine-based eGFR less than 60 ml/min per 1.73 m2 body surface area).
- •Patients who are hemodynamically unstable at time of admission.
- •Mortality within 10 days after admission (duration of study).
Outcomes
Primary Outcomes
Acute kidney injury
Time Frame: 6 days
stages "risk" and "injury" are considered early AKI
Secondary Outcomes
- Adverse neurological outcomes(10 days all except mortality within 28 days)
Investigators
Ahmed Ayman
principle investigator
Alexandria University
Study Sites (1)
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