Kidney Biomarkers for the Prediction of Response to Terlipressin and Survival in Cirrhotic Patients With Acute Kidney Injury: Multicenter, Prospective Cohort Study
试验速览
- 阶段
- 不适用
- 入组人数
- 245
- 试验地点
- 1
- 主要终点
- Overall survival
研究概览
简要总结
The aim of this study is to investigate i) whether two biomarkers (urine NAG, urinary cystatin C) could be predictive factor in patient with liver cirrhosis, , and ii) whether these biomarkers can predict response of terlipressin.
详细描述
Acute kidney injury (AKI) in patients with liver cirrhosis is sometimes accompanied by tubular injury which can lead to poor outcome. Current AKI criteria using serum creatinine (Cr) has some limitations to predict reversibility of renal function and discriminate renal parenchymal injury in cirrhotic patients. The aim of this study is to evaluate whether urine biomarkers [cystatin C, N-acetyl-β-D-Glucosaminidase (NAG)] can predict survival and response to terlipressin in cirrhotic patients with AKI.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with liver cirrhosis diagnosed as acute kidney injury or hepatorenal syndrome
- •Patients who voluntarily agreed to the study
排除标准
- •Patients with active bleeding (eg, varix bleeding) within 7 days
- •Patients with hepatocellular carcinoma
- •Patients with hypersensitivity to terlipressin
- •Patients with anuria
- •Pregnant and lactating patients
- •Patients who did not agree with the study
结局指标
主要结局
Overall survival
时间窗: up to 3 years
From date of sample collection until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 3 years
次要结局
- Transplantation free survival(up to 3 years)
- Regression of acute kidney injury(up to 1 month)
- Recurrence of acute kidney injury(up to 1 year)
- Progression to chronic kidney disease(1 year)
- Response rate to terlipressin(1 week)
研究者
Sang Gyune Kim
Associate proffesor
Soonchunhyang University Hospital