Effects of tumeric and Serrapeptase capsule on reducing pain and improve range of motion in patients with osteoarthritis of the knee
- Conditions
- knee osteoarthritis.Osteoarthritis of knee
- Registration Number
- IRCT20140804018677N8
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 80
age>45y and having knee osteoarthritis according to American College of Rheumatology diagnostic criteria
Knee pain with at least three of the followings: age>50, morning stiffness<30 min, crepitation, bone tenderness at knee, knee bone enlargement, warmness or pain in addition to osteophyte according to radiography
Grade 2 or 3 of osteoarthritis according to Kellgren and Lawrence system
Pain intensity between 5-8 at baseline according to Visual analog scale-VAS
Able to walk independently
not having joint arteritis, orthopedic or severe cardiovascular diseases
intra-articular injection of corticosteroids in past 3 months, as well as gel, and Platelet-rich plasma (PRP) in past year
Severe pain or allergic reaction during intervention that need for Nonsteroidal anti-inflammatory drugs (NSAIDs)
unable to complete the study
BMI>35
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain. Timepoint: Baseline and at the end of the study. Method of measurement: VAS (visual analog scale).;Range of Motion and stiffness. Timepoint: Baseline and at the end of the study. Method of measurement: Western Ontario and McMaster Universities Arthritis Index (WOMAC).
- Secondary Outcome Measures
Name Time Method