Comparison of Curcuma and Russian olive in the Treatment of Knee Osteoarthritis

Not Applicable

Conditions: Osteoarthritis of knee.
Osteoarthritis of knee

Registration Number: IRCT20191216045760N1

Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 50

Inclusion Criteria

Patients older than 45 years
Patients diagnosed with knee osteoarthritis according to the American College of Rheumatology criteria with symptoms for at least 3 months
Knee X-ray as grade 2 or 3 of Kellgren-Lawrence (K-L) classification
Patients' willingness to participate in the study after providing complete information about the project's goals

Exclusion Criteria

Clinical findings in other joints of the body such as hip, wrist or spine.
Evidence of neuropathy such as radiculopathy or peripheral neuropathy
Systemic inflammatory disease such as RA, AS
Fibromyalgia or endocrine and metabolic diseases
Corticosteroid use in the past 48 hours or intra-articular injection of Corticosteroid in the past 4 months
Taking NSAIDs in the past week
Psychiatric disease
Severe blood dyscrasia, coagulopathy, current warfarin use
Liver failure or liver tests more than 1.5 times of normal values
Biliary Disease
PUD or reflux history (GERD)
Renal Failure - Uncontrolled hypertension
Lack of medication compliance in the patient

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Knee pain intensity. Timepoint: Before treatment, 2 and 4 weeks after treatment. Method of measurement: VAS (Visual Analogue Scale).;Symptoms of disease and quality of life. Timepoint: Before treatment, 2 and 4 weeks after treatment. Method of measurement: Knee injury and Osteoarthritis Outcome Score (KOOS).;Function. Timepoint: Before treatment, 2 and 4 weeks after treatment. Method of measurement: Roles and Maudsley score.

Secondary Outcome Measures