IRCT20140804018677N8RecruitingPhase 3
Effects of tumeric (Curcuma longa) and Serrapeptase supplementation on reducing pain and improve range of motion in patients with osteoarthritis of the knee ( a double blind randomized controlled trial)
Conditions
Trial Snapshot
- Phase
- Phase 3
- Status
- Recruiting
- Enrollment
- 80
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 45 years to no limit (—)
- Sex
- All
Inclusion Criteria
- •age>45y and having knee osteoarthritis according to American College of Rheumatology diagnostic criteria
- •Knee pain with at least three of the followings: age>50, morning stiffness<30 min, crepitation, bone tenderness at knee, knee bone enlargement, warmness or pain in addition to osteophyte according to radiography
- •Grade 2 or 3 of osteoarthritis according to Kellgren and Lawrence system
- •Pain intensity between 5-8 at baseline according to Visual analog scale-VAS
- •Able to walk independently
Exclusion Criteria
- •not having joint arteritis, orthopedic or severe cardiovascular diseases
- •intra-articular injection of corticosteroids in past 3 months, as well as gel, and Platelet-rich plasma (PRP) in past year
- •Severe pain or allergic reaction during intervention that need for Nonsteroidal anti-inflammatory drugs (NSAIDs)
- •unable to complete the study
Investigators
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