Gene Polymorphism Study of Normal Individual Inflammasome Genes

Withdrawn

• Conditions: Healthy Individuals
• Interventions: Other: Blood Draw

• Registration Number: NCT01988805
• Lead Sponsor: Ohio State University

Brief Summary

This study is intended to collect blood from healthy individuals to investigate whether variations in immune-related (inflammasome) genes affect how the immune cells found in the blood can help fight infections and prevent diseases.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-02
• Study First Submitted: 2013-11-14
• Study First Submitted QC: 2013-11-14
• Study First Posted: 2013-11-20
• Primary Completion: 2014-02
• Study Completion: 2014-02
• Status Verified: 2014-10
• Last Update Submitted: 2014-10-16
• Last Update Posted: 2014-10-17

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Healthy with no chronic or acute illnesses, or taking medication which in the opinion of the PI would impact the analyses being conducted.
2. At least 18 years or older.
3. Are capable of reading, understanding and providing written informed consent.

Exclusion Criteria

1. Non-English speaking.
2. Individuals under 18 years old.
3. Woman who believe they are or may be pregnant. (Based on self reporting. Pregnancy testing will not be conducted for the purposes of this study)
4. Individuals experiencing acute or chronic illnesses which in the opinion of the PI would impact the analyses being conducted.
5. Currently taking prescription or over the counter medication which in the opinion of the PI would impact the analyses being conducted.
6. Individual has donated blood more than twice in the last week or the amount to be drawn will exceed the maximum allowance in the last 8 weeks.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Blood Draw	Blood Draw	Normal healthy individuals will be consented and their blood drawn at the time of their visit.

Primary Outcome Measures

Name	Time	Method
analyze their ability to respond to exogenous challenges by changing the production of proteins, the expression of genes and their ability to migrate and ingest materials	one visit	Our intent is to collect these cells, divide them into subtypes such as monocytes, lymphocytes and neutrophils and then to analyze their ability to respond to exogenous challenges by changing the production of proteins, the expression of genes and their ability to migrate and ingest materials. We additionally will be interested in examining the cell components that may be released from these cells during various in vitro challenges.

Trial Locations

Locations (1)

Davis Heart & Lung Research Institute; 🇺🇸 Columbus, Ohio, United States