Comparison of Biochemical Changes in Patients With Trochanteric Region Fracture Fixation With Dynamic Hip Screw Versus Proximal Femoral Nail
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hip Fractures
- Sponsor
- Kushtrim Grezda
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- The difference of the level of IL-6 in operated patients.
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Hip fractures are one of the most frequent fractures in older adults. There is still controversy which surgical strategy is the best option for treatment of hip fractures especially trochanteric region fractures. Surgical intervention that follows hip fracture induces biochemical, physiological and fibrinolytic changes that are so-called "second hit phenomenon" which trigger systemic inflammatory response syndrome. The investigators are aiming to study this phenomenon after two different surgical procedures and help surgeons in everyday practice to choose the most suitable surgical treatment for patients with trochanteric region fracture and give the scientific community more evidence which methods is better since there is still controversy.
Investigators
Kushtrim Grezda
Principal Investigator, Clinical Research
University Clinical Centre of Kosova
Eligibility Criteria
Inclusion Criteria
- •Patients with trochanteric region fractures AO/OTA 31.A1-31.A2
- •Time from fracture till surgery up to 1 week
- •American Society of Anesthesiologists Classification (ASA) I-III
- •Willing to participate
Exclusion Criteria
- •Polytrauma patients
- •Open fractures
- •Existing local or systemic infection
- •Pre-existing coagulatory disorder
- •Existing malignancy
- •Corticosteroid use
- •Systemic inflammatory disease
- •Voluntary withdraws of the patient
Outcomes
Primary Outcomes
The difference of the level of IL-6 in operated patients.
Time Frame: 1 hour before and 24 hours after operation
The blood will be collected and after that centrifuged and then stored in -20 grade celsius. The analysis of each sample will be performed no later than 3 months.
Secondary Outcomes
- The difference of the length of operation(Intra-operatively)
- The difference of the level of CRP in operated patients.(1 hour before and 24 hours after operation. Length of operation, length of incision, blood loss perioperatively. Complication and mortality rate within 1 month after OP)
- The difference of the level of D-dimer(1 hour before and 24 hours after operation)
- The difference of the level of ESR(1 hour before and 24 hours after operation)
- The difference of the level of length of incision(After the wound closure)
- Blood loss(Levels of HB before and after surgery. Also the total volume of blood transfusion.)
- Complications after surgery(Within 1 month after surgery)
- Mortality rate(Within 1 month after surgery)