Distraction osteogenesis with culture expanded bone marrow cells for patients with skeletal dysplasias and short stature
Phase 2
- Conditions
- skeletal dysplasias such as achondroplasia and limb length discrepancy
- Registration Number
- JPRN-UMIN000007646
- Lead Sponsor
- agoya University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Not provided
Exclusion Criteria
less than 20kg of body weight
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method healing index
- Secondary Outcome Measures
Name Time Method infection, range of motion, callus formation
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie bone marrow cell expansion in distraction osteogenesis for achondroplasia?
How does culture-expanded bone marrow cell therapy compare to traditional limb lengthening methods in skeletal dysplasias?
Which biomarkers correlate with successful bone regeneration in JPRN-UMIN000007646 trial participants with short stature?
What adverse events are associated with autologous bone marrow cell culture in Phase II skeletal dysplasia trials?
Are there combination therapies involving mesenchymal stem cells or growth factors for enhancing distraction osteogenesis in limb length discrepancy?